Type 1 polyisoprenoid diphosphate phosphatase modulates geranylgeranyl-mediated control of HMG CoA reductase and UBIAD1
UbiA prenyltransferase domain-containing protein-1 (UBIAD1) utilizes geranylgeranyl pyrophosphate (GGpp) to synthesize the vitamin K2 subtype menaquinone-4. The prenyltransferase has emerged as a key regulator of sterol-accelerated, endoplasmic reticulum (ER)-associated degradation (ERAD) of HMG CoA...
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| Main Authors: | , , , , |
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| Format: | article |
| Language: | EN |
| Published: |
eLife Sciences Publications Ltd
2021
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| Subjects: | |
| Online Access: | https://doaj.org/article/7cd4aab5f3a242ce97aaefc96cbb2e1e |
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