Novel FXR agonist nelumal A suppresses colitis and inflammation-related colorectal carcinogenesis

Novel FXR agonist nelumal A suppresses colitis and inflammation-related colorectal carcinogenesis

Abstract FXR is a member of the nuclear receptor superfamily and bile acids are endogenous ligands of FXR. FXR activation has recently been reported to inhibit intestinal inflammation and tumour development. This study aimed to investigate whether the novel FXR agonist nelumal A, the active compound...

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Autores principales: Tsuneyuki Miyazaki, Yohei Shirakami, Taku Mizutani, Akinori Maruta, Takayasu Ideta, Masaya Kubota, Hiroyasu Sakai, Takashi Ibuka, Salvatore Genovese, Serena Fiorito, Vito Alessandro Taddeo, Francesco Epifano, Takuji Tanaka, Masahito Shimizu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/7ce700ce2ce149d58144ddadc34ce01f
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https://doaj.org/article/7ce700ce2ce149d58144ddadc34ce01f

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