Template activating factor-I epigenetically regulates the TERT transcription in human cancer cells

Abstract Telomere, the terminus of linear chromosome in eukaryotes, is composed of specific repeat DNA which is mainly synthesized by a protein complex called telomerase. The maintenance of telomere DNA is important for unlimited proliferative capacity of cancer cells. The telomerase activity is con...

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Bibliographic Details
Main Authors: Kohsuke Kato, Atsushi Kawaguchi, Kyosuke Nagata
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
R
Q
Online Access:https://doaj.org/article/7d5e3641ed684d32bda976d4bba12503
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