The UbiX flavin prenyltransferase reaction mechanism resembles class I terpene cyclase chemistry

The UbiD-UbiX decarboxylase system is required for the biosynthesis of quinone cofactors. Here, the authors combine structural and biochemical analyses to elucidate the UbiX reaction mechanism, showing that it resembles the mode of action of class I terpene cyclases.

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Autores principales:	Stephen A. Marshall, Karl A. P. Payne, Karl Fisher, Mark D. White, Aisling Ní Cheallaigh, Arune Balaikaite, Stephen E. J. Rigby, David Leys
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7d6536e8acd943bea50c5023037c7730
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spelling	oai:doaj.org-article:7d6536e8acd943bea50c5023037c77302021-12-02T17:02:16ZThe UbiX flavin prenyltransferase reaction mechanism resembles class I terpene cyclase chemistry10.1038/s41467-019-10220-12041-1723https://doaj.org/article/7d6536e8acd943bea50c5023037c77302019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10220-1https://doaj.org/toc/2041-1723The UbiD-UbiX decarboxylase system is required for the biosynthesis of quinone cofactors. Here, the authors combine structural and biochemical analyses to elucidate the UbiX reaction mechanism, showing that it resembles the mode of action of class I terpene cyclases.Stephen A. MarshallKarl A. P. PayneKarl FisherMark D. WhiteAisling Ní CheallaighArune BalaikaiteStephen E. J. RigbyDavid LeysNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Stephen A. Marshall Karl A. P. Payne Karl Fisher Mark D. White Aisling Ní Cheallaigh Arune Balaikaite Stephen E. J. Rigby David Leys The UbiX flavin prenyltransferase reaction mechanism resembles class I terpene cyclase chemistry
description	The UbiD-UbiX decarboxylase system is required for the biosynthesis of quinone cofactors. Here, the authors combine structural and biochemical analyses to elucidate the UbiX reaction mechanism, showing that it resembles the mode of action of class I terpene cyclases.
format	article
author	Stephen A. Marshall Karl A. P. Payne Karl Fisher Mark D. White Aisling Ní Cheallaigh Arune Balaikaite Stephen E. J. Rigby David Leys
author_facet	Stephen A. Marshall Karl A. P. Payne Karl Fisher Mark D. White Aisling Ní Cheallaigh Arune Balaikaite Stephen E. J. Rigby David Leys
author_sort	Stephen A. Marshall
title	The UbiX flavin prenyltransferase reaction mechanism resembles class I terpene cyclase chemistry
title_short	The UbiX flavin prenyltransferase reaction mechanism resembles class I terpene cyclase chemistry
title_full	The UbiX flavin prenyltransferase reaction mechanism resembles class I terpene cyclase chemistry
title_fullStr	The UbiX flavin prenyltransferase reaction mechanism resembles class I terpene cyclase chemistry
title_full_unstemmed	The UbiX flavin prenyltransferase reaction mechanism resembles class I terpene cyclase chemistry
title_sort	ubix flavin prenyltransferase reaction mechanism resembles class i terpene cyclase chemistry
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/7d6536e8acd943bea50c5023037c7730
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The UbiX flavin prenyltransferase reaction mechanism resembles class I terpene cyclase chemistry

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