IL-21 restricts T follicular regulatory T cell proliferation through Bcl-6 mediated inhibition of responsiveness to IL-2

IL-21 is central to follicular helper T cell function and germinal centre responses. Here the authors show that IL-21 signalling directly inhibits T follicular regulatory cells by limiting Bcl-6-dependent IL-2 receptor expression.

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Bibliographic Details
Main Authors:	Christoph Jandl, Sue M. Liu, Pablo F. Cañete, Joanna Warren, William E. Hughes, Alexis Vogelzang, Kylie Webster, Maria E. Craig, Gulbu Uzel, Alexander Dent, Polina Stepensky, Bärbel Keller, Klaus Warnatz, Jonathan Sprent, Cecile King
Format:	article
Language:	EN
Published:	Nature Portfolio 2017
Subjects:	Science Q
Online Access:	https://doaj.org/article/7d6cbfdd10b44261bcdec7f07420ffa0
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spelling	oai:doaj.org-article:7d6cbfdd10b44261bcdec7f07420ffa02021-12-02T15:39:06ZIL-21 restricts T follicular regulatory T cell proliferation through Bcl-6 mediated inhibition of responsiveness to IL-210.1038/ncomms146472041-1723https://doaj.org/article/7d6cbfdd10b44261bcdec7f07420ffa02017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14647https://doaj.org/toc/2041-1723IL-21 is central to follicular helper T cell function and germinal centre responses. Here the authors show that IL-21 signalling directly inhibits T follicular regulatory cells by limiting Bcl-6-dependent IL-2 receptor expression.Christoph JandlSue M. LiuPablo F. CañeteJoanna WarrenWilliam E. HughesAlexis VogelzangKylie WebsterMaria E. CraigGulbu UzelAlexander DentPolina StepenskyBärbel KellerKlaus WarnatzJonathan SprentCecile KingNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Christoph Jandl Sue M. Liu Pablo F. Cañete Joanna Warren William E. Hughes Alexis Vogelzang Kylie Webster Maria E. Craig Gulbu Uzel Alexander Dent Polina Stepensky Bärbel Keller Klaus Warnatz Jonathan Sprent Cecile King IL-21 restricts T follicular regulatory T cell proliferation through Bcl-6 mediated inhibition of responsiveness to IL-2
description	IL-21 is central to follicular helper T cell function and germinal centre responses. Here the authors show that IL-21 signalling directly inhibits T follicular regulatory cells by limiting Bcl-6-dependent IL-2 receptor expression.
format	article
author	Christoph Jandl Sue M. Liu Pablo F. Cañete Joanna Warren William E. Hughes Alexis Vogelzang Kylie Webster Maria E. Craig Gulbu Uzel Alexander Dent Polina Stepensky Bärbel Keller Klaus Warnatz Jonathan Sprent Cecile King
author_facet	Christoph Jandl Sue M. Liu Pablo F. Cañete Joanna Warren William E. Hughes Alexis Vogelzang Kylie Webster Maria E. Craig Gulbu Uzel Alexander Dent Polina Stepensky Bärbel Keller Klaus Warnatz Jonathan Sprent Cecile King
author_sort	Christoph Jandl
title	IL-21 restricts T follicular regulatory T cell proliferation through Bcl-6 mediated inhibition of responsiveness to IL-2
title_short	IL-21 restricts T follicular regulatory T cell proliferation through Bcl-6 mediated inhibition of responsiveness to IL-2
title_full	IL-21 restricts T follicular regulatory T cell proliferation through Bcl-6 mediated inhibition of responsiveness to IL-2
title_fullStr	IL-21 restricts T follicular regulatory T cell proliferation through Bcl-6 mediated inhibition of responsiveness to IL-2
title_full_unstemmed	IL-21 restricts T follicular regulatory T cell proliferation through Bcl-6 mediated inhibition of responsiveness to IL-2
title_sort	il-21 restricts t follicular regulatory t cell proliferation through bcl-6 mediated inhibition of responsiveness to il-2
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/7d6cbfdd10b44261bcdec7f07420ffa0
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IL-21 restricts T follicular regulatory T cell proliferation through Bcl-6 mediated inhibition of responsiveness to IL-2

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