Yap regulates skeletal muscle fatty acid oxidation and adiposity in metabolic disease

Yap regulates skeletal muscle fatty acid oxidation and adiposity in metabolic disease

The mechanisms driving metabolic dysfunction in obesity remain incompletely understood. Here, the authors show that the levels of Hippo pathway effector YAP are reduced in muscle from individuals with insulin resistance and obese-diabetic mice, and that YAP promotes skeletal muscle lipid metabolism...

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Autores principales: K. I. Watt, D. C. Henstridge, M. Ziemann, C. B. Sim, M. K. Montgomery, D. Samocha-Bonet, B. L. Parker, G. T. Dodd, S. T. Bond, T. M. Salmi, R. S. Lee, R. E. Thomson, A. Hagg, J. R. Davey, H. Qian, R. Koopman, A. El-Osta, J. R. Greenfield, M. J. Watt, M. A. Febbraio, B. G. Drew, A. G. Cox, E. R. Porrello, K. F. Harvey, P. Gregorevic
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/7dcbc3af56b043379fc3d456b0978176
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Sumario:The mechanisms driving metabolic dysfunction in obesity remain incompletely understood. Here, the authors show that the levels of Hippo pathway effector YAP are reduced in muscle from individuals with insulin resistance and obese-diabetic mice, and that YAP promotes skeletal muscle lipid metabolism and limits adiposity in obese mice.

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