Yap regulates skeletal muscle fatty acid oxidation and adiposity in metabolic disease

The mechanisms driving metabolic dysfunction in obesity remain incompletely understood. Here, the authors show that the levels of Hippo pathway effector YAP are reduced in muscle from individuals with insulin resistance and obese-diabetic mice, and that YAP promotes skeletal muscle lipid metabolism...

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Autores principales:	K. I. Watt, D. C. Henstridge, M. Ziemann, C. B. Sim, M. K. Montgomery, D. Samocha-Bonet, B. L. Parker, G. T. Dodd, S. T. Bond, T. M. Salmi, R. S. Lee, R. E. Thomson, A. Hagg, J. R. Davey, H. Qian, R. Koopman, A. El-Osta, J. R. Greenfield, M. J. Watt, M. A. Febbraio, B. G. Drew, A. G. Cox, E. R. Porrello, K. F. Harvey, P. Gregorevic
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7dcbc3af56b043379fc3d456b0978176
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spelling	oai:doaj.org-article:7dcbc3af56b043379fc3d456b09781762021-12-02T14:58:50ZYap regulates skeletal muscle fatty acid oxidation and adiposity in metabolic disease10.1038/s41467-021-23240-72041-1723https://doaj.org/article/7dcbc3af56b043379fc3d456b09781762021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23240-7https://doaj.org/toc/2041-1723The mechanisms driving metabolic dysfunction in obesity remain incompletely understood. Here, the authors show that the levels of Hippo pathway effector YAP are reduced in muscle from individuals with insulin resistance and obese-diabetic mice, and that YAP promotes skeletal muscle lipid metabolism and limits adiposity in obese mice.K. I. WattD. C. HenstridgeM. ZiemannC. B. SimM. K. MontgomeryD. Samocha-BonetB. L. ParkerG. T. DoddS. T. BondT. M. SalmiR. S. LeeR. E. ThomsonA. HaggJ. R. DaveyH. QianR. KoopmanA. El-OstaJ. R. GreenfieldM. J. WattM. A. FebbraioB. G. DrewA. G. CoxE. R. PorrelloK. F. HarveyP. GregorevicNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q K. I. Watt D. C. Henstridge M. Ziemann C. B. Sim M. K. Montgomery D. Samocha-Bonet B. L. Parker G. T. Dodd S. T. Bond T. M. Salmi R. S. Lee R. E. Thomson A. Hagg J. R. Davey H. Qian R. Koopman A. El-Osta J. R. Greenfield M. J. Watt M. A. Febbraio B. G. Drew A. G. Cox E. R. Porrello K. F. Harvey P. Gregorevic Yap regulates skeletal muscle fatty acid oxidation and adiposity in metabolic disease
description	The mechanisms driving metabolic dysfunction in obesity remain incompletely understood. Here, the authors show that the levels of Hippo pathway effector YAP are reduced in muscle from individuals with insulin resistance and obese-diabetic mice, and that YAP promotes skeletal muscle lipid metabolism and limits adiposity in obese mice.
format	article
author	K. I. Watt D. C. Henstridge M. Ziemann C. B. Sim M. K. Montgomery D. Samocha-Bonet B. L. Parker G. T. Dodd S. T. Bond T. M. Salmi R. S. Lee R. E. Thomson A. Hagg J. R. Davey H. Qian R. Koopman A. El-Osta J. R. Greenfield M. J. Watt M. A. Febbraio B. G. Drew A. G. Cox E. R. Porrello K. F. Harvey P. Gregorevic
author_facet	K. I. Watt D. C. Henstridge M. Ziemann C. B. Sim M. K. Montgomery D. Samocha-Bonet B. L. Parker G. T. Dodd S. T. Bond T. M. Salmi R. S. Lee R. E. Thomson A. Hagg J. R. Davey H. Qian R. Koopman A. El-Osta J. R. Greenfield M. J. Watt M. A. Febbraio B. G. Drew A. G. Cox E. R. Porrello K. F. Harvey P. Gregorevic
author_sort	K. I. Watt
title	Yap regulates skeletal muscle fatty acid oxidation and adiposity in metabolic disease
title_short	Yap regulates skeletal muscle fatty acid oxidation and adiposity in metabolic disease
title_full	Yap regulates skeletal muscle fatty acid oxidation and adiposity in metabolic disease
title_fullStr	Yap regulates skeletal muscle fatty acid oxidation and adiposity in metabolic disease
title_full_unstemmed	Yap regulates skeletal muscle fatty acid oxidation and adiposity in metabolic disease
title_sort	yap regulates skeletal muscle fatty acid oxidation and adiposity in metabolic disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7dcbc3af56b043379fc3d456b0978176
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Yap regulates skeletal muscle fatty acid oxidation and adiposity in metabolic disease

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