Photoprotective effects of apple peel nanoparticles

Devasier Bennet,1 Se Chan Kang,2 Jongback Gang,3 Sanghyo Kim1,4 1Department of Bionanotechnology, 2Department of Life Science, 3Department of Nano Chemistry, Gachon University, Bokjeong-Dong, Sujeong-Gu, Seongnam-Si, Gyeonggi-Do, Republic of Korea; 4Graduate Gachon Medical Research Institute, Gil M...

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Autores principales:	Bennet D, Kang SC, Gang J, Kim S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/7dcbe4e807ae495c8601715fd09fcddf
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spelling	oai:doaj.org-article:7dcbe4e807ae495c8601715fd09fcddf2021-12-02T04:18:56ZPhotoprotective effects of apple peel nanoparticles1178-2013https://doaj.org/article/7dcbe4e807ae495c8601715fd09fcddf2013-12-01T00:00:00Zhttp://www.dovepress.com/photoprotective-effects-of-apple-peel-nanoparticles-a15329https://doaj.org/toc/1178-2013 Devasier Bennet,1 Se Chan Kang,2 Jongback Gang,3 Sanghyo Kim1,4 1Department of Bionanotechnology, 2Department of Life Science, 3Department of Nano Chemistry, Gachon University, Bokjeong-Dong, Sujeong-Gu, Seongnam-Si, Gyeonggi-Do, Republic of Korea; 4Graduate Gachon Medical Research Institute, Gil Medical Center, Inchon, Republic of Korea Abstract: Plants contain enriched bioactive molecules that can protect against skin diseases. Bioactive molecules become unstable and ineffective due to unfavorable conditions. In the present study, to improve the therapeutic efficacy of phytodrugs and enhance photoprotective capability, we used poly(D,L-lactide-co-glycolide) as a carrier of apple peel ethanolic extract (APETE) on permeation-enhanced nanoparticles (nano-APETE). The in vitro toxicity of nano-APETE-treated dermal fibroblast cells were studied in a bioimpedance system, and the results coincided with the viability assay. In addition, the continuous real-time evaluations of photodamage and photoprotective effect of nano-APETE on cells were studied. Among three different preparations of nano-APETE, the lowest concentration provided small, spherical, monodispersed, uniform particles which show high encapsulation, enhanced uptake, effective scavenging, and sustained intracellular delivery. Also, the nano-APETE is more flexible, allowing it to permeate through skin lipid membrane and release the drug in a sustained manner, thus confirming its ability as a sustained transdermal delivery. In summary, 50 µM nano-APETE shows strong synergistic photoprotective effects, thus demonstrating its higher activity on target sites for the treatment of skin damage, and would be of broad interest in the field of skin therapeutics. Keywords: apple peel ethanolic extract, antioxidant, cellular uptake, electric cell-substrate impedance sensing, phyto-drugs, light-induced damageBennet DKang SCGang JKim SDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Issue 1, Pp 93-108 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Bennet D Kang SC Gang J Kim S Photoprotective effects of apple peel nanoparticles
description	Devasier Bennet,1 Se Chan Kang,2 Jongback Gang,3 Sanghyo Kim1,4 1Department of Bionanotechnology, 2Department of Life Science, 3Department of Nano Chemistry, Gachon University, Bokjeong-Dong, Sujeong-Gu, Seongnam-Si, Gyeonggi-Do, Republic of Korea; 4Graduate Gachon Medical Research Institute, Gil Medical Center, Inchon, Republic of Korea Abstract: Plants contain enriched bioactive molecules that can protect against skin diseases. Bioactive molecules become unstable and ineffective due to unfavorable conditions. In the present study, to improve the therapeutic efficacy of phytodrugs and enhance photoprotective capability, we used poly(D,L-lactide-co-glycolide) as a carrier of apple peel ethanolic extract (APETE) on permeation-enhanced nanoparticles (nano-APETE). The in vitro toxicity of nano-APETE-treated dermal fibroblast cells were studied in a bioimpedance system, and the results coincided with the viability assay. In addition, the continuous real-time evaluations of photodamage and photoprotective effect of nano-APETE on cells were studied. Among three different preparations of nano-APETE, the lowest concentration provided small, spherical, monodispersed, uniform particles which show high encapsulation, enhanced uptake, effective scavenging, and sustained intracellular delivery. Also, the nano-APETE is more flexible, allowing it to permeate through skin lipid membrane and release the drug in a sustained manner, thus confirming its ability as a sustained transdermal delivery. In summary, 50 µM nano-APETE shows strong synergistic photoprotective effects, thus demonstrating its higher activity on target sites for the treatment of skin damage, and would be of broad interest in the field of skin therapeutics. Keywords: apple peel ethanolic extract, antioxidant, cellular uptake, electric cell-substrate impedance sensing, phyto-drugs, light-induced damage
format	article
author	Bennet D Kang SC Gang J Kim S
author_facet	Bennet D Kang SC Gang J Kim S
author_sort	Bennet D
title	Photoprotective effects of apple peel nanoparticles
title_short	Photoprotective effects of apple peel nanoparticles
title_full	Photoprotective effects of apple peel nanoparticles
title_fullStr	Photoprotective effects of apple peel nanoparticles
title_full_unstemmed	Photoprotective effects of apple peel nanoparticles
title_sort	photoprotective effects of apple peel nanoparticles
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/7dcbe4e807ae495c8601715fd09fcddf
work_keys_str_mv	AT bennetd photoprotectiveeffectsofapplepeelnanoparticles AT kangsc photoprotectiveeffectsofapplepeelnanoparticles AT gangj photoprotectiveeffectsofapplepeelnanoparticles AT kims photoprotectiveeffectsofapplepeelnanoparticles
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Photoprotective effects of apple peel nanoparticles

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