Matrilin3/TGFβ3 gelatin microparticles promote chondrogenesis, prevent hypertrophy, and induce paracrine release in MSC spheroid for disc regeneration

Abstract Degenerative disc disease (DDD) is the leading cause of excruciating lower back pain and disability in adults worldwide. Among the current treatments for DDD, cell-based therapies such as the injection of both disc- and non-disc-derived chondrocytes have shown significant improvements in th...

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Autores principales: Alvin Bacero Bello, Yunkyung Kim, Sunghyun Park, Manjunatha S. Muttigi, Jiseong Kim, Hansoo Park, Soohong Lee
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/7de8c9d1ebed42328e651f3ec0bbee73
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