Arginase II Promotes Intervertebral Disc Degeneration Through Exacerbating Senescence and Apoptosis Caused by Oxidative Stress and Inflammation via the NF-κB Pathway

Arginase II Promotes Intervertebral Disc Degeneration Through Exacerbating Senescence and Apoptosis Caused by Oxidative Stress and Inflammation via the NF-κB Pathway

Intervertebral disc degeneration (IDD) has been generally accepted as the major cause of low back pain (LBP), which imposes massive clinical and socioeconomic burdens. Previous studies have demonstrated that oxidative stress and inflammation-induced senescence and apoptosis of nucleus pulposus cells...

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Main Authors: Fudong Li, Xiaofei Sun, Bing Zheng, Kaiqiang Sun, Jian Zhu, Chenglong Ji, Feng Lin, Le Huan, Xi Luo, Chen Yan, Jiashun Xu, Yun Hong, Yuan Wang, Ximing Xu, Jingchuan Sun, Zheming Song, Fanqi Kong, Jiangang Shi
Format: article
Language:EN
Published: Frontiers Media S.A. 2021
Subjects:
ARG2
intervertebral disc degeneration
nucleus pulposus
oxidative stress
inflammatory response
senescence
Biology (General)
QH301-705.5
Online Access:https://doaj.org/article/7e04b2bd64bd4cf8b79e34906b8da1e9
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https://doaj.org/article/7e04b2bd64bd4cf8b79e34906b8da1e9

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