Managing Contamination and Diverse Bacterial Loads in 16S rRNA Deep Sequencing of Clinical Samples: Implications of the Law of Small Numbers
There has been a gradual increase in 16S deep sequencing studies on infectious disease materials. Management of bacterial DNA contamination is a major challenge in such diagnostics, particularly in low biomass samples.
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Main Authors: | Ruben Dyrhovden, Martin Rippin, Kjell Kåre Øvrebø, Randi M. Nygaard, Elling Ulvestad, Øyvind Kommedal |
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Format: | article |
Language: | EN |
Published: |
American Society for Microbiology
2021
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Online Access: | https://doaj.org/article/7e158acfaad245d589d8e7bb2c45acab |
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