S1P/S1P<sub>2</sub> Signaling Axis Regulates Both NLRP3 Upregulation and NLRP3 Inflammasome Activation in Macrophages Primed with Lipopolysaccharide

The activation of NLRP3 inflammasome is a key factor for various inflammatory diseases. Here, we provide experimental evidence supporting the regulatory role of sphingosine-1-phosphate (S1P) in NLRP3 inflammasome activation in mouse bone-marrow-derived macrophages (BMDMs), along with the S1P recepto...

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Autores principales: Chi-Ho Lee, Ji Woong Choi
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
S1P
LPS
Acceso en línea:https://doaj.org/article/7e20c0f07dec4bf4ac2bcc30dcb53a7e
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