Peptide-oligourea hybrids analogue of GLP-1 with improved action in vivo

The peptide hormone GLP-1 has the potential to be a remedy for diabetes type II, yet is unstable. Here, the authors synthesized α-peptide-oligourea hybrid analogues of GLP-1 some of which showing significantly prolonged activity in vivo.

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Autores principales: Juliette Fremaux, Claire Venin, Laura Mauran, Robert H. Zimmer, Gilles Guichard, Sébastien R. Goudreau
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/7e2c09e5f5e9452e9f698d011ed0817b
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