Peptide-oligourea hybrids analogue of GLP-1 with improved action in vivo

The peptide hormone GLP-1 has the potential to be a remedy for diabetes type II, yet is unstable. Here, the authors synthesized α-peptide-oligourea hybrid analogues of GLP-1 some of which showing significantly prolonged activity in vivo.

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Autores principales:	Juliette Fremaux, Claire Venin, Laura Mauran, Robert H. Zimmer, Gilles Guichard, Sébastien R. Goudreau
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7e2c09e5f5e9452e9f698d011ed0817b
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spelling	oai:doaj.org-article:7e2c09e5f5e9452e9f698d011ed0817b2021-12-02T15:35:06ZPeptide-oligourea hybrids analogue of GLP-1 with improved action in vivo10.1038/s41467-019-08793-y2041-1723https://doaj.org/article/7e2c09e5f5e9452e9f698d011ed0817b2019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08793-yhttps://doaj.org/toc/2041-1723The peptide hormone GLP-1 has the potential to be a remedy for diabetes type II, yet is unstable. Here, the authors synthesized α-peptide-oligourea hybrid analogues of GLP-1 some of which showing significantly prolonged activity in vivo.Juliette FremauxClaire VeninLaura MauranRobert H. ZimmerGilles GuichardSébastien R. GoudreauNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Juliette Fremaux Claire Venin Laura Mauran Robert H. Zimmer Gilles Guichard Sébastien R. Goudreau Peptide-oligourea hybrids analogue of GLP-1 with improved action in vivo
description	The peptide hormone GLP-1 has the potential to be a remedy for diabetes type II, yet is unstable. Here, the authors synthesized α-peptide-oligourea hybrid analogues of GLP-1 some of which showing significantly prolonged activity in vivo.
format	article
author	Juliette Fremaux Claire Venin Laura Mauran Robert H. Zimmer Gilles Guichard Sébastien R. Goudreau
author_facet	Juliette Fremaux Claire Venin Laura Mauran Robert H. Zimmer Gilles Guichard Sébastien R. Goudreau
author_sort	Juliette Fremaux
title	Peptide-oligourea hybrids analogue of GLP-1 with improved action in vivo
title_short	Peptide-oligourea hybrids analogue of GLP-1 with improved action in vivo
title_full	Peptide-oligourea hybrids analogue of GLP-1 with improved action in vivo
title_fullStr	Peptide-oligourea hybrids analogue of GLP-1 with improved action in vivo
title_full_unstemmed	Peptide-oligourea hybrids analogue of GLP-1 with improved action in vivo
title_sort	peptide-oligourea hybrids analogue of glp-1 with improved action in vivo
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/7e2c09e5f5e9452e9f698d011ed0817b
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Peptide-oligourea hybrids analogue of GLP-1 with improved action in vivo

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