Differential organization of tonic and chronic B cell antigen receptors in the plasma membrane

Signalling of the B cell receptor (BCR) is pivotal for survival and activation of naïve B cells. Here the authors show, using super-resolution microscopy techniques, that BCRs exist primarily as monomers and dimers in resting B cells, and oligomerize only on stimulation, thereby implicating a functi...

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Autores principales:	Maria Angela Gomes de Castro, Hanna Wildhagen, Shama Sograte-Idrissi, Christoffer Hitzing, Mascha Binder, Martin Trepel, Niklas Engels, Felipe Opazo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7e46cbba11b14a6585cafa271c7104a1
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spelling	oai:doaj.org-article:7e46cbba11b14a6585cafa271c7104a12021-12-02T17:32:10ZDifferential organization of tonic and chronic B cell antigen receptors in the plasma membrane10.1038/s41467-019-08677-12041-1723https://doaj.org/article/7e46cbba11b14a6585cafa271c7104a12019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08677-1https://doaj.org/toc/2041-1723Signalling of the B cell receptor (BCR) is pivotal for survival and activation of naïve B cells. Here the authors show, using super-resolution microscopy techniques, that BCRs exist primarily as monomers and dimers in resting B cells, and oligomerize only on stimulation, thereby implicating a function of BCR clustering patterns on B cell biology.Maria Angela Gomes de CastroHanna WildhagenShama Sograte-IdrissiChristoffer HitzingMascha BinderMartin TrepelNiklas EngelsFelipe OpazoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Maria Angela Gomes de Castro Hanna Wildhagen Shama Sograte-Idrissi Christoffer Hitzing Mascha Binder Martin Trepel Niklas Engels Felipe Opazo Differential organization of tonic and chronic B cell antigen receptors in the plasma membrane
description	Signalling of the B cell receptor (BCR) is pivotal for survival and activation of naïve B cells. Here the authors show, using super-resolution microscopy techniques, that BCRs exist primarily as monomers and dimers in resting B cells, and oligomerize only on stimulation, thereby implicating a function of BCR clustering patterns on B cell biology.
format	article
author	Maria Angela Gomes de Castro Hanna Wildhagen Shama Sograte-Idrissi Christoffer Hitzing Mascha Binder Martin Trepel Niklas Engels Felipe Opazo
author_facet	Maria Angela Gomes de Castro Hanna Wildhagen Shama Sograte-Idrissi Christoffer Hitzing Mascha Binder Martin Trepel Niklas Engels Felipe Opazo
author_sort	Maria Angela Gomes de Castro
title	Differential organization of tonic and chronic B cell antigen receptors in the plasma membrane
title_short	Differential organization of tonic and chronic B cell antigen receptors in the plasma membrane
title_full	Differential organization of tonic and chronic B cell antigen receptors in the plasma membrane
title_fullStr	Differential organization of tonic and chronic B cell antigen receptors in the plasma membrane
title_full_unstemmed	Differential organization of tonic and chronic B cell antigen receptors in the plasma membrane
title_sort	differential organization of tonic and chronic b cell antigen receptors in the plasma membrane
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/7e46cbba11b14a6585cafa271c7104a1
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Differential organization of tonic and chronic B cell antigen receptors in the plasma membrane

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