Insights into the initiation of JC virus DNA replication derived from the crystal structure of the T-antigen origin binding domain.

JC virus is a member of the Polyomavirus family of DNA tumor viruses and the causative agent of progressive multifocal leukoencephalopathy (PML). PML is a disease that occurs primarily in people who are immunocompromised and is usually fatal. As with other Polyomavirus family members, the replicatio...

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Autores principales: Gretchen Meinke, Paul J Phelan, Radha Kalekar, Jong Shin, Jacques Archambault, Andrew Bohm, Peter A Bullock
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
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Acceso en línea:https://doaj.org/article/7e4b30b6762a45c09e6e596efe3849e3
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