Caveolin-1-mediated sphingolipid oncometabolism underlies a metabolic vulnerability of prostate cancer

The mechanisms associated with Caveolin-1 (Cav-1) mediated metabolic changes in prostate cancer are unclear. Here, the authors show that Cav-1 promotes rewiring of cancer cell lipid metabolism towards a program of exogenous lipid scavenging and vesicle biogenesis that intersects with mitochondrial d...

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Autores principales:	Jody Vykoukal, Johannes F. Fahrmann, Justin R. Gregg, Zhe Tang, Spyridon Basourakos, Ehsan Irajizad, Sanghee Park, Guang Yang, Chad J. Creighton, Alia Fleury, Jeffrey Mayo, Adriana Paulucci-Holthauzen, Jennifer B. Dennison, Eunice Murage, Christine B. Peterson, John W. Davis, Jeri Kim, Samir Hanash, Timothy C. Thompson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7eaa659d0fae432bb96a1cf469b289ce
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spelling	oai:doaj.org-article:7eaa659d0fae432bb96a1cf469b289ce2021-12-02T15:09:18ZCaveolin-1-mediated sphingolipid oncometabolism underlies a metabolic vulnerability of prostate cancer10.1038/s41467-020-17645-z2041-1723https://doaj.org/article/7eaa659d0fae432bb96a1cf469b289ce2020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17645-zhttps://doaj.org/toc/2041-1723The mechanisms associated with Caveolin-1 (Cav-1) mediated metabolic changes in prostate cancer are unclear. Here, the authors show that Cav-1 promotes rewiring of cancer cell lipid metabolism towards a program of exogenous lipid scavenging and vesicle biogenesis that intersects with mitochondrial dynamics in prostate tumors.Jody VykoukalJohannes F. FahrmannJustin R. GreggZhe TangSpyridon BasourakosEhsan IrajizadSanghee ParkGuang YangChad J. CreightonAlia FleuryJeffrey MayoAdriana Paulucci-HolthauzenJennifer B. DennisonEunice MurageChristine B. PetersonJohn W. DavisJeri KimSamir HanashTimothy C. ThompsonNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jody Vykoukal Johannes F. Fahrmann Justin R. Gregg Zhe Tang Spyridon Basourakos Ehsan Irajizad Sanghee Park Guang Yang Chad J. Creighton Alia Fleury Jeffrey Mayo Adriana Paulucci-Holthauzen Jennifer B. Dennison Eunice Murage Christine B. Peterson John W. Davis Jeri Kim Samir Hanash Timothy C. Thompson Caveolin-1-mediated sphingolipid oncometabolism underlies a metabolic vulnerability of prostate cancer
description	The mechanisms associated with Caveolin-1 (Cav-1) mediated metabolic changes in prostate cancer are unclear. Here, the authors show that Cav-1 promotes rewiring of cancer cell lipid metabolism towards a program of exogenous lipid scavenging and vesicle biogenesis that intersects with mitochondrial dynamics in prostate tumors.
format	article
author	Jody Vykoukal Johannes F. Fahrmann Justin R. Gregg Zhe Tang Spyridon Basourakos Ehsan Irajizad Sanghee Park Guang Yang Chad J. Creighton Alia Fleury Jeffrey Mayo Adriana Paulucci-Holthauzen Jennifer B. Dennison Eunice Murage Christine B. Peterson John W. Davis Jeri Kim Samir Hanash Timothy C. Thompson
author_facet	Jody Vykoukal Johannes F. Fahrmann Justin R. Gregg Zhe Tang Spyridon Basourakos Ehsan Irajizad Sanghee Park Guang Yang Chad J. Creighton Alia Fleury Jeffrey Mayo Adriana Paulucci-Holthauzen Jennifer B. Dennison Eunice Murage Christine B. Peterson John W. Davis Jeri Kim Samir Hanash Timothy C. Thompson
author_sort	Jody Vykoukal
title	Caveolin-1-mediated sphingolipid oncometabolism underlies a metabolic vulnerability of prostate cancer
title_short	Caveolin-1-mediated sphingolipid oncometabolism underlies a metabolic vulnerability of prostate cancer
title_full	Caveolin-1-mediated sphingolipid oncometabolism underlies a metabolic vulnerability of prostate cancer
title_fullStr	Caveolin-1-mediated sphingolipid oncometabolism underlies a metabolic vulnerability of prostate cancer
title_full_unstemmed	Caveolin-1-mediated sphingolipid oncometabolism underlies a metabolic vulnerability of prostate cancer
title_sort	caveolin-1-mediated sphingolipid oncometabolism underlies a metabolic vulnerability of prostate cancer
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/7eaa659d0fae432bb96a1cf469b289ce
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Caveolin-1-mediated sphingolipid oncometabolism underlies a metabolic vulnerability of prostate cancer

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