Stepwise reprogramming of liver cells to a pancreas progenitor state by the transcriptional regulator Tgif2

Stepwise reprogramming of liver cells to a pancreas progenitor state by the transcriptional regulator Tgif2

Liver and pancreas cells arise from a common endoderm progenitor in the embryo, but what regulates their cell fate is unclear. Here, the authors show that expression of the Three-Amino-acid-Loop-Extension (TALE) homeobox TG-interacting factor 2 (TGIF2) in hepatocytes reprogrammes the cells to a panc...

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Bibliographic Details
Main Authors: Nuria Cerdá-Esteban, Heike Naumann, Silvia Ruzittu, Nancy Mah, Igor M. Pongrac, Corinna Cozzitorto, Angela Hommel, Miguel A. Andrade-Navarro, Ezio Bonifacio, Francesca M. Spagnoli
Format: article
Language:EN
Published: Nature Portfolio 2017
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Science
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Online Access:https://doaj.org/article/7ebdf3d8a92040efa4c2ffd160f951bf
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