p38 regulates the tumor suppressor PDCD4 via the TSC-mTORC1 pathway

Programmed cell death protein 4 (PDCD4) exerts critical functions as tumor suppressor and in immune cells to regulate inflammatory pro-cesses. The phosphoinositide 3-kinase (PI3K) promotes degradation of PDCD4 via mammalian target of rapamycin complex 1 (mTORC1). How-ever, additional pathways that m...

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Autores principales:	Clarissa Braun, Karl Katholnig, Christopher Kaltenecker, Monika Linke, Nyamdelger Sukhbaatar, Markus Hengstschläger, Thomas Weichhart
Formato:	article
Lenguaje:	EN
Publicado:	Shared Science Publishers OG 2021
Materias:	macrophages cancer rapamycin mk2 pdcd4 p38 mtorc1 tsc1 tsc2 Medicine R Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/7ec40a35d4504ab8b854afe0d4185ef4
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id	oai:doaj.org-article:7ec40a35d4504ab8b854afe0d4185ef4
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spelling	oai:doaj.org-article:7ec40a35d4504ab8b854afe0d4185ef42021-12-05T17:54:50Zp38 regulates the tumor suppressor PDCD4 via the TSC-mTORC1 pathway2523-020410.15698/cst2021.11.260https://doaj.org/article/7ec40a35d4504ab8b854afe0d4185ef42021-11-01T00:00:00Zhttp://www.cell-stress.com/researcharticles/2021a-braun-cell-stress/https://doaj.org/toc/2523-0204Programmed cell death protein 4 (PDCD4) exerts critical functions as tumor suppressor and in immune cells to regulate inflammatory pro-cesses. The phosphoinositide 3-kinase (PI3K) promotes degradation of PDCD4 via mammalian target of rapamycin complex 1 (mTORC1). How-ever, additional pathways that may regulate PDCD4 expression are largely ill-defined. In this study, we have found that activation of the mitogen-activated protein kinase p38 promoted degradation of PDCD4 in macrophages and fibroblasts. Mechanistically, we identified a path-way from p38 and its substrate MAP kinase-activated protein kinase 2 (MK2) to the tuberous sclerosis complex (TSC) to regulate mTORC1-dependent degradation of PDCD4. Moreover, we provide evidence that TSC1 and TSC2 regulate PDCD4 expression via an additional mechanism independent of mTORC1. These novel data extend our knowledge of how PDCD4 expression is regulated by stress- and nutrient-sensing pathways.Clarissa BraunKarl KatholnigChristopher KalteneckerMonika LinkeNyamdelger SukhbaatarMarkus HengstschlägerThomas WeichhartShared Science Publishers OGarticlemacrophagescancerrapamycinmk2pdcd4p38mtorc1tsc1tsc2MedicineRBiology (General)QH301-705.5ENCell Stress, Vol 5, Iss 12, Pp 176-182 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	macrophages cancer rapamycin mk2 pdcd4 p38 mtorc1 tsc1 tsc2 Medicine R Biology (General) QH301-705.5
spellingShingle	macrophages cancer rapamycin mk2 pdcd4 p38 mtorc1 tsc1 tsc2 Medicine R Biology (General) QH301-705.5 Clarissa Braun Karl Katholnig Christopher Kaltenecker Monika Linke Nyamdelger Sukhbaatar Markus Hengstschläger Thomas Weichhart p38 regulates the tumor suppressor PDCD4 via the TSC-mTORC1 pathway
description	Programmed cell death protein 4 (PDCD4) exerts critical functions as tumor suppressor and in immune cells to regulate inflammatory pro-cesses. The phosphoinositide 3-kinase (PI3K) promotes degradation of PDCD4 via mammalian target of rapamycin complex 1 (mTORC1). How-ever, additional pathways that may regulate PDCD4 expression are largely ill-defined. In this study, we have found that activation of the mitogen-activated protein kinase p38 promoted degradation of PDCD4 in macrophages and fibroblasts. Mechanistically, we identified a path-way from p38 and its substrate MAP kinase-activated protein kinase 2 (MK2) to the tuberous sclerosis complex (TSC) to regulate mTORC1-dependent degradation of PDCD4. Moreover, we provide evidence that TSC1 and TSC2 regulate PDCD4 expression via an additional mechanism independent of mTORC1. These novel data extend our knowledge of how PDCD4 expression is regulated by stress- and nutrient-sensing pathways.
format	article
author	Clarissa Braun Karl Katholnig Christopher Kaltenecker Monika Linke Nyamdelger Sukhbaatar Markus Hengstschläger Thomas Weichhart
author_facet	Clarissa Braun Karl Katholnig Christopher Kaltenecker Monika Linke Nyamdelger Sukhbaatar Markus Hengstschläger Thomas Weichhart
author_sort	Clarissa Braun
title	p38 regulates the tumor suppressor PDCD4 via the TSC-mTORC1 pathway
title_short	p38 regulates the tumor suppressor PDCD4 via the TSC-mTORC1 pathway
title_full	p38 regulates the tumor suppressor PDCD4 via the TSC-mTORC1 pathway
title_fullStr	p38 regulates the tumor suppressor PDCD4 via the TSC-mTORC1 pathway
title_full_unstemmed	p38 regulates the tumor suppressor PDCD4 via the TSC-mTORC1 pathway
title_sort	p38 regulates the tumor suppressor pdcd4 via the tsc-mtorc1 pathway
publisher	Shared Science Publishers OG
publishDate	2021
url	https://doaj.org/article/7ec40a35d4504ab8b854afe0d4185ef4
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p38 regulates the tumor suppressor PDCD4 via the TSC-mTORC1 pathway

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