Integrated lipidomics and proteomics reveal cardiolipin alterations, upregulation of HADHA and long chain fatty acids in pancreatic cancer stem cells

Integrated lipidomics and proteomics reveal cardiolipin alterations, upregulation of HADHA and long chain fatty acids in pancreatic cancer stem cells

Abstract Pancreatic cancer stem cells (PCSCs) play a key role in the aggressiveness of pancreatic ductal adenocarcinomas (PDAC); however, little is known about their signaling and metabolic pathways. Here we show that PCSCs have specific and common proteome and lipidome modulations. PCSCs displayed...

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Bibliographic Details
Main Authors: Claudia Di Carlo, Bebiana C. Sousa, Marcello Manfredi, Jessica Brandi, Elisa Dalla Pozza, Emilio Marengo, Marta Palmieri, Ilaria Dando, Michael J. O. Wakelam, Andrea F. Lopez-Clavijo, Daniela Cecconi
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/7ecf05d9ceac409bb21256e8799d63d9
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https://doaj.org/article/7ecf05d9ceac409bb21256e8799d63d9

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