Integrated lipidomics and proteomics reveal cardiolipin alterations, upregulation of HADHA and long chain fatty acids in pancreatic cancer stem cells

Integrated lipidomics and proteomics reveal cardiolipin alterations, upregulation of HADHA and long chain fatty acids in pancreatic cancer stem cells

Abstract Pancreatic cancer stem cells (PCSCs) play a key role in the aggressiveness of pancreatic ductal adenocarcinomas (PDAC); however, little is known about their signaling and metabolic pathways. Here we show that PCSCs have specific and common proteome and lipidome modulations. PCSCs displayed...

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Autores principales: Claudia Di Carlo, Bebiana C. Sousa, Marcello Manfredi, Jessica Brandi, Elisa Dalla Pozza, Emilio Marengo, Marta Palmieri, Ilaria Dando, Michael J. O. Wakelam, Andrea F. Lopez-Clavijo, Daniela Cecconi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/7ecf05d9ceac409bb21256e8799d63d9
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