Clostridium botulinum strain Af84 contains three neurotoxin gene clusters: bont/A2, bont/F4 and bont/F5.

Sanger and shotgun sequencing of Clostridium botulinum strain Af84 type Af and its botulinum neurotoxin gene (bont) clusters identified the presence of three bont gene clusters rather than the expected two. The three toxin gene clusters consisted of bont subtypes A2, F4 and F5. The bont/A2 and bont/...

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Autores principales:	Nir Dover, Jason R Barash, Karen K Hill, Karen W Davenport, Hazuki Teshima, Gary Xie, Stephen S Arnon
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7ef0677d00dc4def879d4e17ac746bf8
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spelling	oai:doaj.org-article:7ef0677d00dc4def879d4e17ac746bf82021-11-18T07:49:32ZClostridium botulinum strain Af84 contains three neurotoxin gene clusters: bont/A2, bont/F4 and bont/F5.1932-620310.1371/journal.pone.0061205https://doaj.org/article/7ef0677d00dc4def879d4e17ac746bf82013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23637798/?tool=EBIhttps://doaj.org/toc/1932-6203Sanger and shotgun sequencing of Clostridium botulinum strain Af84 type Af and its botulinum neurotoxin gene (bont) clusters identified the presence of three bont gene clusters rather than the expected two. The three toxin gene clusters consisted of bont subtypes A2, F4 and F5. The bont/A2 and bont/F4 gene clusters were located within the chromosome (the latter in a novel location), while the bont/F5 toxin gene cluster was located within a large 246 kb plasmid. These findings are the first identification of a C. botulinum strain that contains three botulinum neurotoxin gene clusters.Nir DoverJason R BarashKaren K HillKaren W DavenportHazuki TeshimaGary XieStephen S ArnonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 4, p e61205 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nir Dover Jason R Barash Karen K Hill Karen W Davenport Hazuki Teshima Gary Xie Stephen S Arnon Clostridium botulinum strain Af84 contains three neurotoxin gene clusters: bont/A2, bont/F4 and bont/F5.
description	Sanger and shotgun sequencing of Clostridium botulinum strain Af84 type Af and its botulinum neurotoxin gene (bont) clusters identified the presence of three bont gene clusters rather than the expected two. The three toxin gene clusters consisted of bont subtypes A2, F4 and F5. The bont/A2 and bont/F4 gene clusters were located within the chromosome (the latter in a novel location), while the bont/F5 toxin gene cluster was located within a large 246 kb plasmid. These findings are the first identification of a C. botulinum strain that contains three botulinum neurotoxin gene clusters.
format	article
author	Nir Dover Jason R Barash Karen K Hill Karen W Davenport Hazuki Teshima Gary Xie Stephen S Arnon
author_facet	Nir Dover Jason R Barash Karen K Hill Karen W Davenport Hazuki Teshima Gary Xie Stephen S Arnon
author_sort	Nir Dover
title	Clostridium botulinum strain Af84 contains three neurotoxin gene clusters: bont/A2, bont/F4 and bont/F5.
title_short	Clostridium botulinum strain Af84 contains three neurotoxin gene clusters: bont/A2, bont/F4 and bont/F5.
title_full	Clostridium botulinum strain Af84 contains three neurotoxin gene clusters: bont/A2, bont/F4 and bont/F5.
title_fullStr	Clostridium botulinum strain Af84 contains three neurotoxin gene clusters: bont/A2, bont/F4 and bont/F5.
title_full_unstemmed	Clostridium botulinum strain Af84 contains three neurotoxin gene clusters: bont/A2, bont/F4 and bont/F5.
title_sort	clostridium botulinum strain af84 contains three neurotoxin gene clusters: bont/a2, bont/f4 and bont/f5.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/7ef0677d00dc4def879d4e17ac746bf8
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Clostridium botulinum strain Af84 contains three neurotoxin gene clusters: bont/A2, bont/F4 and bont/F5.

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