Disease-relevant transcriptional signatures identified in individual smooth muscle cells from healthy mouse vessels

Vascular smooth muscle cell (VSMC) accumulation is associated with cardiovascular disease. Here, the authors combine single-cell RNA sequencing with lineage labelling to profile VSMC heterogeneity in healthy mice. They show that upregulation of Sca1 in a rare VSMC subpopulation marks a cell phenotyp...

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Autores principales: Lina Dobnikar, Annabel L. Taylor, Joel Chappell, Phoebe Oldach, Jennifer L. Harman, Erin Oerton, Elaine Dzierzak, Martin R. Bennett, Mikhail Spivakov, Helle F. Jørgensen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/7ef92bdb43ed4a47aa8f77c7bd990947
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