Disease-relevant transcriptional signatures identified in individual smooth muscle cells from healthy mouse vessels

Vascular smooth muscle cell (VSMC) accumulation is associated with cardiovascular disease. Here, the authors combine single-cell RNA sequencing with lineage labelling to profile VSMC heterogeneity in healthy mice. They show that upregulation of Sca1 in a rare VSMC subpopulation marks a cell phenotyp...

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Autores principales:	Lina Dobnikar, Annabel L. Taylor, Joel Chappell, Phoebe Oldach, Jennifer L. Harman, Erin Oerton, Elaine Dzierzak, Martin R. Bennett, Mikhail Spivakov, Helle F. Jørgensen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7ef92bdb43ed4a47aa8f77c7bd990947
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spelling	oai:doaj.org-article:7ef92bdb43ed4a47aa8f77c7bd9909472021-12-02T14:38:50ZDisease-relevant transcriptional signatures identified in individual smooth muscle cells from healthy mouse vessels10.1038/s41467-018-06891-x2041-1723https://doaj.org/article/7ef92bdb43ed4a47aa8f77c7bd9909472018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06891-xhttps://doaj.org/toc/2041-1723Vascular smooth muscle cell (VSMC) accumulation is associated with cardiovascular disease. Here, the authors combine single-cell RNA sequencing with lineage labelling to profile VSMC heterogeneity in healthy mice. They show that upregulation of Sca1 in a rare VSMC subpopulation marks a cell phenotype that is prevalent in disease.Lina DobnikarAnnabel L. TaylorJoel ChappellPhoebe OldachJennifer L. HarmanErin OertonElaine DzierzakMartin R. BennettMikhail SpivakovHelle F. JørgensenNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lina Dobnikar Annabel L. Taylor Joel Chappell Phoebe Oldach Jennifer L. Harman Erin Oerton Elaine Dzierzak Martin R. Bennett Mikhail Spivakov Helle F. Jørgensen Disease-relevant transcriptional signatures identified in individual smooth muscle cells from healthy mouse vessels
description	Vascular smooth muscle cell (VSMC) accumulation is associated with cardiovascular disease. Here, the authors combine single-cell RNA sequencing with lineage labelling to profile VSMC heterogeneity in healthy mice. They show that upregulation of Sca1 in a rare VSMC subpopulation marks a cell phenotype that is prevalent in disease.
format	article
author	Lina Dobnikar Annabel L. Taylor Joel Chappell Phoebe Oldach Jennifer L. Harman Erin Oerton Elaine Dzierzak Martin R. Bennett Mikhail Spivakov Helle F. Jørgensen
author_facet	Lina Dobnikar Annabel L. Taylor Joel Chappell Phoebe Oldach Jennifer L. Harman Erin Oerton Elaine Dzierzak Martin R. Bennett Mikhail Spivakov Helle F. Jørgensen
author_sort	Lina Dobnikar
title	Disease-relevant transcriptional signatures identified in individual smooth muscle cells from healthy mouse vessels
title_short	Disease-relevant transcriptional signatures identified in individual smooth muscle cells from healthy mouse vessels
title_full	Disease-relevant transcriptional signatures identified in individual smooth muscle cells from healthy mouse vessels
title_fullStr	Disease-relevant transcriptional signatures identified in individual smooth muscle cells from healthy mouse vessels
title_full_unstemmed	Disease-relevant transcriptional signatures identified in individual smooth muscle cells from healthy mouse vessels
title_sort	disease-relevant transcriptional signatures identified in individual smooth muscle cells from healthy mouse vessels
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/7ef92bdb43ed4a47aa8f77c7bd990947
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Disease-relevant transcriptional signatures identified in individual smooth muscle cells from healthy mouse vessels

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