Disease-relevant transcriptional signatures identified in individual smooth muscle cells from healthy mouse vessels
Vascular smooth muscle cell (VSMC) accumulation is associated with cardiovascular disease. Here, the authors combine single-cell RNA sequencing with lineage labelling to profile VSMC heterogeneity in healthy mice. They show that upregulation of Sca1 in a rare VSMC subpopulation marks a cell phenotyp...
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Autores principales: | Lina Dobnikar, Annabel L. Taylor, Joel Chappell, Phoebe Oldach, Jennifer L. Harman, Erin Oerton, Elaine Dzierzak, Martin R. Bennett, Mikhail Spivakov, Helle F. Jørgensen |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2018
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Materias: | |
Acceso en línea: | https://doaj.org/article/7ef92bdb43ed4a47aa8f77c7bd990947 |
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