A Review of Calcineurin Biophysics with Implications for Cardiac Physiology

Calcineurin, also known as protein phosphatase 2B, is a heterodimeric serine threonine phosphatase involved in numerous signaling pathways. During the past 50 years, calcineurin has been the subject of extensive investigation. Many of its cellular and physiological functions have been described, and...

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Main Authors:	Ryan B. Williams, Christopher N. Johnson
Format:	article
Language:	EN
Published:	MDPI AG 2021
Subjects:	calcineurin phosphatase protein phosphatase 2B (PP2B) calcium signaling calmodulin cardiomyocyte Biology (General) QH301-705.5 Chemistry QD1-999
Online Access:	https://doaj.org/article/7f15c9367f794532bd0f3f73cb4ae4fe
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id	oai:doaj.org-article:7f15c9367f794532bd0f3f73cb4ae4fe
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spelling	oai:doaj.org-article:7f15c9367f794532bd0f3f73cb4ae4fe2021-11-11T17:02:55ZA Review of Calcineurin Biophysics with Implications for Cardiac Physiology10.3390/ijms2221115651422-00671661-6596https://doaj.org/article/7f15c9367f794532bd0f3f73cb4ae4fe2021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11565https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Calcineurin, also known as protein phosphatase 2B, is a heterodimeric serine threonine phosphatase involved in numerous signaling pathways. During the past 50 years, calcineurin has been the subject of extensive investigation. Many of its cellular and physiological functions have been described, and the underlying biophysical mechanisms are the subject of active investigation. With the abundance of techniques and experimental designs utilized to study calcineurin and its numerous substrates, it is difficult to reconcile the available information. There have been a plethora of reports describing the role of calcineurin in cardiac disease. However, a physiological role of calcineurin in healthy cardiomyocyte function requires clarification. Here, we review the seminal biophysical and structural details that are responsible for the molecular function and inhibition of calcineurin. We then focus on literature describing the roles of calcineurin in cardiomyocyte physiology and disease.Ryan B. WilliamsChristopher N. JohnsonMDPI AGarticlecalcineurinphosphataseprotein phosphatase 2B (PP2B)calcium signalingcalmodulincardiomyocyteBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11565, p 11565 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	calcineurin phosphatase protein phosphatase 2B (PP2B) calcium signaling calmodulin cardiomyocyte Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	calcineurin phosphatase protein phosphatase 2B (PP2B) calcium signaling calmodulin cardiomyocyte Biology (General) QH301-705.5 Chemistry QD1-999 Ryan B. Williams Christopher N. Johnson A Review of Calcineurin Biophysics with Implications for Cardiac Physiology
description	Calcineurin, also known as protein phosphatase 2B, is a heterodimeric serine threonine phosphatase involved in numerous signaling pathways. During the past 50 years, calcineurin has been the subject of extensive investigation. Many of its cellular and physiological functions have been described, and the underlying biophysical mechanisms are the subject of active investigation. With the abundance of techniques and experimental designs utilized to study calcineurin and its numerous substrates, it is difficult to reconcile the available information. There have been a plethora of reports describing the role of calcineurin in cardiac disease. However, a physiological role of calcineurin in healthy cardiomyocyte function requires clarification. Here, we review the seminal biophysical and structural details that are responsible for the molecular function and inhibition of calcineurin. We then focus on literature describing the roles of calcineurin in cardiomyocyte physiology and disease.
format	article
author	Ryan B. Williams Christopher N. Johnson
author_facet	Ryan B. Williams Christopher N. Johnson
author_sort	Ryan B. Williams
title	A Review of Calcineurin Biophysics with Implications for Cardiac Physiology
title_short	A Review of Calcineurin Biophysics with Implications for Cardiac Physiology
title_full	A Review of Calcineurin Biophysics with Implications for Cardiac Physiology
title_fullStr	A Review of Calcineurin Biophysics with Implications for Cardiac Physiology
title_full_unstemmed	A Review of Calcineurin Biophysics with Implications for Cardiac Physiology
title_sort	review of calcineurin biophysics with implications for cardiac physiology
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/7f15c9367f794532bd0f3f73cb4ae4fe
work_keys_str_mv	AT ryanbwilliams areviewofcalcineurinbiophysicswithimplicationsforcardiacphysiology AT christophernjohnson areviewofcalcineurinbiophysicswithimplicationsforcardiacphysiology AT ryanbwilliams reviewofcalcineurinbiophysicswithimplicationsforcardiacphysiology AT christophernjohnson reviewofcalcineurinbiophysicswithimplicationsforcardiacphysiology
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A Review of Calcineurin Biophysics with Implications for Cardiac Physiology

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