Synthesis and Antiproliferative Evaluation of 3-Chloroazetidin-2-ones with Antimitotic Activity: Heterocyclic Bridged Analogues of Combretastatin A-4

Synthesis and Antiproliferative Evaluation of 3-Chloroazetidin-2-ones with Antimitotic Activity: Heterocyclic Bridged Analogues of Combretastatin A-4

Antimitotic drugs that target tubulin are among the most widely used chemotherapeutic agents; however, the development of multidrug resistance has limited their clinical activity. We report the synthesis and biological properties of a series of novel 3-chloro-β-lactams and 3,3-dichloro-β-lactams (2-...

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Autores principales: Azizah M. Malebari, Shu Wang, Thomas F. Greene, Niamh M. O’Boyle, Darren Fayne, Mohemmed Faraz Khan, Seema M. Nathwani, Brendan Twamley, Thomas McCabe, Daniela M. Zisterer, Mary J. Meegan
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
β-lactam
3-chloroazetidin-2-ones
antimitotic
antiproliferative activity
breast cancer
tubulin polymerisation
Medicine
R
Pharmacy and materia medica
RS1-441
Acceso en línea:https://doaj.org/article/7f2b0031e7fb41bc8378c9286946a121
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https://doaj.org/article/7f2b0031e7fb41bc8378c9286946a121

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