His6, His13, and His14 residues in Aβ 1–40 peptide significantly and specifically affect oligomeric equilibria

Abstract Oligomers of Aβ peptide are implicated as the most probable causative agent in Alzheimer’s disease. However, their structural properties remain elusive due to the dynamic and heterogeneous character of oligomeric species coexisting in solution. Nevertheless, new approaches, mainly based on...

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Autores principales:	Kaja Przygońska, Magdalena Pacewicz, Wiktoria Sadowska, Jarosław Poznański, Wojciech Bal, Michał Dadlez
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7f3beb276d5440eb9a6d11c0aedd833e
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spelling	oai:doaj.org-article:7f3beb276d5440eb9a6d11c0aedd833e2021-12-02T16:08:04ZHis6, His13, and His14 residues in Aβ 1–40 peptide significantly and specifically affect oligomeric equilibria10.1038/s41598-019-45988-12045-2322https://doaj.org/article/7f3beb276d5440eb9a6d11c0aedd833e2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-45988-1https://doaj.org/toc/2045-2322Abstract Oligomers of Aβ peptide are implicated as the most probable causative agent in Alzheimer’s disease. However, their structural properties remain elusive due to the dynamic and heterogeneous character of oligomeric species coexisting in solution. Nevertheless, new approaches, mainly based on mass spectrometry, provide unique access to these different structural forms. Using these methods, we previously showed that the N-terminal, non-amyloidogenic region of Aβ is involved in the network of interactions specifically stabilizing oligomers. In the present study, we identified three histidine residues as active participants in this network. Detailed knowledge of the structural features that are potentially important for oligomer-mediated neurotoxicity is a prerequisite for the rational design of oligomerization modifiers.Kaja PrzygońskaMagdalena PacewiczWiktoria SadowskaJarosław PoznańskiWojciech BalMichał DadlezNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kaja Przygońska Magdalena Pacewicz Wiktoria Sadowska Jarosław Poznański Wojciech Bal Michał Dadlez His6, His13, and His14 residues in Aβ 1–40 peptide significantly and specifically affect oligomeric equilibria
description	Abstract Oligomers of Aβ peptide are implicated as the most probable causative agent in Alzheimer’s disease. However, their structural properties remain elusive due to the dynamic and heterogeneous character of oligomeric species coexisting in solution. Nevertheless, new approaches, mainly based on mass spectrometry, provide unique access to these different structural forms. Using these methods, we previously showed that the N-terminal, non-amyloidogenic region of Aβ is involved in the network of interactions specifically stabilizing oligomers. In the present study, we identified three histidine residues as active participants in this network. Detailed knowledge of the structural features that are potentially important for oligomer-mediated neurotoxicity is a prerequisite for the rational design of oligomerization modifiers.
format	article
author	Kaja Przygońska Magdalena Pacewicz Wiktoria Sadowska Jarosław Poznański Wojciech Bal Michał Dadlez
author_facet	Kaja Przygońska Magdalena Pacewicz Wiktoria Sadowska Jarosław Poznański Wojciech Bal Michał Dadlez
author_sort	Kaja Przygońska
title	His6, His13, and His14 residues in Aβ 1–40 peptide significantly and specifically affect oligomeric equilibria
title_short	His6, His13, and His14 residues in Aβ 1–40 peptide significantly and specifically affect oligomeric equilibria
title_full	His6, His13, and His14 residues in Aβ 1–40 peptide significantly and specifically affect oligomeric equilibria
title_fullStr	His6, His13, and His14 residues in Aβ 1–40 peptide significantly and specifically affect oligomeric equilibria
title_full_unstemmed	His6, His13, and His14 residues in Aβ 1–40 peptide significantly and specifically affect oligomeric equilibria
title_sort	his6, his13, and his14 residues in aβ 1–40 peptide significantly and specifically affect oligomeric equilibria
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/7f3beb276d5440eb9a6d11c0aedd833e
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His6, His13, and His14 residues in Aβ 1–40 peptide significantly and specifically affect oligomeric equilibria

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