ATRX is a regulator of therapy induced senescence in human cells

Therapy induced senescence (TIS) is a growth suppressive program activated by cytostatic agents in some cancer cells. Here the authors show that the chromatin remodeling enzyme ATRX is a regulator of TIS and drives cells into this state via multiple mechanisms.

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Autores principales: Marta Kovatcheva, Will Liao, Mary E. Klein, Nicolas Robine, Heather Geiger, Aimee M. Crago, Mark A. Dickson, William D. Tap, Samuel Singer, Andrew Koff
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/7f628acc50d64801af6befbeedb96ee3
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