ATRX is a regulator of therapy induced senescence in human cells

Therapy induced senescence (TIS) is a growth suppressive program activated by cytostatic agents in some cancer cells. Here the authors show that the chromatin remodeling enzyme ATRX is a regulator of TIS and drives cells into this state via multiple mechanisms.

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Autores principales:	Marta Kovatcheva, Will Liao, Mary E. Klein, Nicolas Robine, Heather Geiger, Aimee M. Crago, Mark A. Dickson, William D. Tap, Samuel Singer, Andrew Koff
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7f628acc50d64801af6befbeedb96ee3
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spelling	oai:doaj.org-article:7f628acc50d64801af6befbeedb96ee32021-12-02T15:38:33ZATRX is a regulator of therapy induced senescence in human cells10.1038/s41467-017-00540-52041-1723https://doaj.org/article/7f628acc50d64801af6befbeedb96ee32017-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00540-5https://doaj.org/toc/2041-1723Therapy induced senescence (TIS) is a growth suppressive program activated by cytostatic agents in some cancer cells. Here the authors show that the chromatin remodeling enzyme ATRX is a regulator of TIS and drives cells into this state via multiple mechanisms.Marta KovatchevaWill LiaoMary E. KleinNicolas RobineHeather GeigerAimee M. CragoMark A. DicksonWilliam D. TapSamuel SingerAndrew KoffNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marta Kovatcheva Will Liao Mary E. Klein Nicolas Robine Heather Geiger Aimee M. Crago Mark A. Dickson William D. Tap Samuel Singer Andrew Koff ATRX is a regulator of therapy induced senescence in human cells
description	Therapy induced senescence (TIS) is a growth suppressive program activated by cytostatic agents in some cancer cells. Here the authors show that the chromatin remodeling enzyme ATRX is a regulator of TIS and drives cells into this state via multiple mechanisms.
format	article
author	Marta Kovatcheva Will Liao Mary E. Klein Nicolas Robine Heather Geiger Aimee M. Crago Mark A. Dickson William D. Tap Samuel Singer Andrew Koff
author_facet	Marta Kovatcheva Will Liao Mary E. Klein Nicolas Robine Heather Geiger Aimee M. Crago Mark A. Dickson William D. Tap Samuel Singer Andrew Koff
author_sort	Marta Kovatcheva
title	ATRX is a regulator of therapy induced senescence in human cells
title_short	ATRX is a regulator of therapy induced senescence in human cells
title_full	ATRX is a regulator of therapy induced senescence in human cells
title_fullStr	ATRX is a regulator of therapy induced senescence in human cells
title_full_unstemmed	ATRX is a regulator of therapy induced senescence in human cells
title_sort	atrx is a regulator of therapy induced senescence in human cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/7f628acc50d64801af6befbeedb96ee3
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ATRX is a regulator of therapy induced senescence in human cells

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