DNA crosslinking and recombination‐activating genes 1/2 (RAG1/2) are required for oncogenic splicing in acute lymphoblastic leukemia

DNA crosslinking and recombination‐activating genes 1/2 (RAG1/2) are required for oncogenic splicing in acute lymphoblastic leukemia

Abstract Background Abnormal alternative splicing is frequently associated with carcinogenesis. In B‐cell acute lymphoblastic leukemia (B‐ALL), double homeobox 4 fused with immunoglobulin heavy chain (DUX4/IGH) can lead to the aberrant production of E‐26 transformation‐specific family related gene a...

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Main Authors: Hao Zhang, Nuo Cheng, Zhihui Li, Ling Bai, Chengli Fang, Yuwen Li, Weina Zhang, Xue Dong, Minghao Jiang, Yang Liang, Sujiang Zhang, Jianqing Mi, Jiang Zhu, Yu Zhang, Sai‐Juan Chen, Yajie Zhao, Xiang‐Qin Weng, Weiguo Hu, Zhu Chen, Jinyan Huang, Guoyu Meng
Format: article
Language:EN
Published: Wiley 2021
Subjects:
Acute lymphoblastic leukemia
alternative splicing
DUX4/IGH
ERGalt
RAG1/2
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Online Access:https://doaj.org/article/7fca2b2f3c82432b857e2e6044af3125
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https://doaj.org/article/7fca2b2f3c82432b857e2e6044af3125

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