In Silico Structure-Guided Optimization and Molecular Simulation Studies of 3-Phenoxy-4-(3-trifluoromethylphenyl)pyridazines as Potent Phytoene Desaturase Inhibitors
A series of novel 3-phenoxy-4-(3-trifluoromethylphenyl)pyridazines <b>2</b>–<b>5</b> were designed, based on the structure of our previous lead compound <b>1</b> through the in silico structure-guided optimization approach. The results showed that some of these ne...
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| Auteurs principaux: | , , , , , , , |
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| Format: | article |
| Langue: | EN |
| Publié: |
MDPI AG
2021
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| Accès en ligne: | https://doaj.org/article/800a4978bc0b481ab5f2eb95f431b2ac |
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