Trans-Ned 19-Mediated Antagonism of Nicotinic Acid Adenine Nucleotide—Mediated Calcium Signaling Regulates Th17 Cell Plasticity in Mice

Trans-Ned 19-Mediated Antagonism of Nicotinic Acid Adenine Nucleotide—Mediated Calcium Signaling Regulates Th17 Cell Plasticity in Mice

Nicotinic acid adenine dinucleotide phosphate (NAADP) is the most potent Ca<sup>2+</sup> mobilizing agent and its inhibition proved to inhibit T-cell activation. However, the impact of the NAADP signaling on CD4<sup>+</sup> T-cell differentiation and plasticity and on the inf...

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Bibliographic Details
Main Authors: Mikołaj Nawrocki, Niels Lory, Tanja Bedke, Friederike Stumme, Björn-Phillip Diercks, Andreas H. Guse, Chris Meier, Nicola Gagliani, Hans-Willi Mittrücker, Samuel Huber
Format: article
Language:EN
Published: MDPI AG 2021
Subjects:
adenine nucleotides
NAADP
Ca<sup>2+</sup> signaling
T cells
immune regulation
inflammatory diseases
Biology (General)
QH301-705.5
Online Access:https://doaj.org/article/800f263d5f3a4bb294d1ec4fe5002247
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https://doaj.org/article/800f263d5f3a4bb294d1ec4fe5002247

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