Phosphorylation of EB2 by Aurora B and CDK1 ensures mitotic progression and genome stability

Temporal regulation of microtubule dynamics in mitosis can be achieved by phosphorylation of microtubule plus-end proteins. Here, the authors show that Aurora B and CDK1 phosphorylate EB2, which changes microtubule binding affinity and controls kinetochore microtubule dynamics and genome stability.

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Autores principales: Makoto Iimori, Sugiko Watanabe, Shinichi Kiyonari, Kazuaki Matsuoka, Ryo Sakasai, Hiroshi Saeki, Eiji Oki, Hiroyuki Kitao, Yoshihiko Maehara
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/802977d060344b0a800fe1f75bcb688a
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Sumario:Temporal regulation of microtubule dynamics in mitosis can be achieved by phosphorylation of microtubule plus-end proteins. Here, the authors show that Aurora B and CDK1 phosphorylate EB2, which changes microtubule binding affinity and controls kinetochore microtubule dynamics and genome stability.