Phosphorylation of EB2 by Aurora B and CDK1 ensures mitotic progression and genome stability

Phosphorylation of EB2 by Aurora B and CDK1 ensures mitotic progression and genome stability

Temporal regulation of microtubule dynamics in mitosis can be achieved by phosphorylation of microtubule plus-end proteins. Here, the authors show that Aurora B and CDK1 phosphorylate EB2, which changes microtubule binding affinity and controls kinetochore microtubule dynamics and genome stability.

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Autores principales: Makoto Iimori, Sugiko Watanabe, Shinichi Kiyonari, Kazuaki Matsuoka, Ryo Sakasai, Hiroshi Saeki, Eiji Oki, Hiroyuki Kitao, Yoshihiko Maehara
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/802977d060344b0a800fe1f75bcb688a
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spelling oai:doaj.org-article:802977d060344b0a800fe1f75bcb688a2021-12-02T14:39:13ZPhosphorylation of EB2 by Aurora B and CDK1 ensures mitotic progression and genome stability10.1038/ncomms111172041-1723https://doaj.org/article/802977d060344b0a800fe1f75bcb688a2016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms11117https://doaj.org/toc/2041-1723Temporal regulation of microtubule dynamics in mitosis can be achieved by phosphorylation of microtubule plus-end proteins. Here, the authors show that Aurora B and CDK1 phosphorylate EB2, which changes microtubule binding affinity and controls kinetochore microtubule dynamics and genome stability.Makoto IimoriSugiko WatanabeShinichi KiyonariKazuaki MatsuokaRyo SakasaiHiroshi SaekiEiji OkiHiroyuki KitaoYoshihiko MaeharaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Makoto Iimori
Sugiko Watanabe
Shinichi Kiyonari
Kazuaki Matsuoka
Ryo Sakasai
Hiroshi Saeki
Eiji Oki
Hiroyuki Kitao
Yoshihiko Maehara
Phosphorylation of EB2 by Aurora B and CDK1 ensures mitotic progression and genome stability
description Temporal regulation of microtubule dynamics in mitosis can be achieved by phosphorylation of microtubule plus-end proteins. Here, the authors show that Aurora B and CDK1 phosphorylate EB2, which changes microtubule binding affinity and controls kinetochore microtubule dynamics and genome stability.
format article
author Makoto Iimori
Sugiko Watanabe
Shinichi Kiyonari
Kazuaki Matsuoka
Ryo Sakasai
Hiroshi Saeki
Eiji Oki
Hiroyuki Kitao
Yoshihiko Maehara
author_facet Makoto Iimori
Sugiko Watanabe
Shinichi Kiyonari
Kazuaki Matsuoka
Ryo Sakasai
Hiroshi Saeki
Eiji Oki
Hiroyuki Kitao
Yoshihiko Maehara
author_sort Makoto Iimori
title Phosphorylation of EB2 by Aurora B and CDK1 ensures mitotic progression and genome stability
title_short Phosphorylation of EB2 by Aurora B and CDK1 ensures mitotic progression and genome stability
title_full Phosphorylation of EB2 by Aurora B and CDK1 ensures mitotic progression and genome stability
title_fullStr Phosphorylation of EB2 by Aurora B and CDK1 ensures mitotic progression and genome stability
title_full_unstemmed Phosphorylation of EB2 by Aurora B and CDK1 ensures mitotic progression and genome stability
title_sort phosphorylation of eb2 by aurora b and cdk1 ensures mitotic progression and genome stability
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/802977d060344b0a800fe1f75bcb688a
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AT sugikowatanabe phosphorylationofeb2byaurorabandcdk1ensuresmitoticprogressionandgenomestability
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