Cardiomyocytes stimulate angiogenesis after ischemic injury in a ZEB2-dependent manner

ZEB2 transcription factor is increased in a subset of cardiomyocytes during stress to induce cardioprotective effects after injury. Here the authors show that therapeutic delivery of ZEB2 prevents cardiac dysfunction after ischemic damage and promotes the activation of pro-angiogenic signals.

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Autores principales:	Monika M. Gladka, Arwa Kohela, Bas Molenaar, Danielle Versteeg, Lieneke Kooijman, Jantine Monshouwer-Kloots, Veerle Kremer, Harmjan R. Vos, Manon M. H. Huibers, Jody J. Haigh, Danny Huylebroeck, Reinier A. Boon, Mauro Giacca, Eva van Rooij
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/802a0b24eda04cdd86b100e349bc9eb1
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spelling	oai:doaj.org-article:802a0b24eda04cdd86b100e349bc9eb12021-12-02T11:56:18ZCardiomyocytes stimulate angiogenesis after ischemic injury in a ZEB2-dependent manner10.1038/s41467-020-20361-32041-1723https://doaj.org/article/802a0b24eda04cdd86b100e349bc9eb12021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20361-3https://doaj.org/toc/2041-1723ZEB2 transcription factor is increased in a subset of cardiomyocytes during stress to induce cardioprotective effects after injury. Here the authors show that therapeutic delivery of ZEB2 prevents cardiac dysfunction after ischemic damage and promotes the activation of pro-angiogenic signals.Monika M. GladkaArwa KohelaBas MolenaarDanielle VersteegLieneke KooijmanJantine Monshouwer-KlootsVeerle KremerHarmjan R. VosManon M. H. HuibersJody J. HaighDanny HuylebroeckReinier A. BoonMauro GiaccaEva van RooijNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Monika M. Gladka Arwa Kohela Bas Molenaar Danielle Versteeg Lieneke Kooijman Jantine Monshouwer-Kloots Veerle Kremer Harmjan R. Vos Manon M. H. Huibers Jody J. Haigh Danny Huylebroeck Reinier A. Boon Mauro Giacca Eva van Rooij Cardiomyocytes stimulate angiogenesis after ischemic injury in a ZEB2-dependent manner
description	ZEB2 transcription factor is increased in a subset of cardiomyocytes during stress to induce cardioprotective effects after injury. Here the authors show that therapeutic delivery of ZEB2 prevents cardiac dysfunction after ischemic damage and promotes the activation of pro-angiogenic signals.
format	article
author	Monika M. Gladka Arwa Kohela Bas Molenaar Danielle Versteeg Lieneke Kooijman Jantine Monshouwer-Kloots Veerle Kremer Harmjan R. Vos Manon M. H. Huibers Jody J. Haigh Danny Huylebroeck Reinier A. Boon Mauro Giacca Eva van Rooij
author_facet	Monika M. Gladka Arwa Kohela Bas Molenaar Danielle Versteeg Lieneke Kooijman Jantine Monshouwer-Kloots Veerle Kremer Harmjan R. Vos Manon M. H. Huibers Jody J. Haigh Danny Huylebroeck Reinier A. Boon Mauro Giacca Eva van Rooij
author_sort	Monika M. Gladka
title	Cardiomyocytes stimulate angiogenesis after ischemic injury in a ZEB2-dependent manner
title_short	Cardiomyocytes stimulate angiogenesis after ischemic injury in a ZEB2-dependent manner
title_full	Cardiomyocytes stimulate angiogenesis after ischemic injury in a ZEB2-dependent manner
title_fullStr	Cardiomyocytes stimulate angiogenesis after ischemic injury in a ZEB2-dependent manner
title_full_unstemmed	Cardiomyocytes stimulate angiogenesis after ischemic injury in a ZEB2-dependent manner
title_sort	cardiomyocytes stimulate angiogenesis after ischemic injury in a zeb2-dependent manner
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/802a0b24eda04cdd86b100e349bc9eb1
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Cardiomyocytes stimulate angiogenesis after ischemic injury in a ZEB2-dependent manner

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