A dual binding mode for RhoGTPases in plexin signalling.

Plexins are cell surface receptors for the semaphorin family of cell guidance cues. The cytoplasmic region comprises a Ras GTPase-activating protein (GAP) domain and a RhoGTPase binding domain. Concomitant binding of extracellular semaphorin and intracellular RhoGTPase triggers GAP activity and sign...

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Auteurs principaux: Christian H Bell, A Radu Aricescu, E Yvonne Jones, Christian Siebold
Format: article
Langue:EN
Publié: Public Library of Science (PLoS) 2011
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Accès en ligne:https://doaj.org/article/802b9e5141fe449e9c5be833e0a97e31
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