Cytoplasmic location of α1A voltage-gated calcium channel C-terminal fragment (Cav2.1-CTF) aggregate is sufficient to cause cell death.

Cytoplasmic location of α1A voltage-gated calcium channel C-terminal fragment (Cav2.1-CTF) aggregate is sufficient to cause cell death.

The human α1A voltage-dependent calcium channel (Cav2.1) is a pore-forming essential subunit embedded in the plasma membrane. Its cytoplasmic carboxyl(C)-tail contains a small poly-glutamine (Q) tract, whose length is normally 4∼19 Q, but when expanded up to 20∼33Q, the tract causes an autosomal-dom...

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Main Authors: Makoto Takahashi, Masato Obayashi, Taro Ishiguro, Nozomu Sato, Yusuke Niimi, Kokoro Ozaki, Kaoru Mogushi, Yasen Mahmut, Hiroshi Tanaka, Fuminori Tsuruta, Ricardo Dolmetsch, Mitsunori Yamada, Hitoshi Takahashi, Takeo Kato, Osamu Mori, Yoshinobu Eishi, Hidehiro Mizusawa, Kinya Ishikawa
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2013
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/8044bf9c01c34e3db29cdef49ee568b3
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