Ubiquitin transfer by a RING E3 ligase occurs from a closed E2~ubiquitin conformation
The mechanism of ubiquitin transfer from the ubiquitin-conjugated E2 enzyme (E2~Ub) to the substrate is still under debate. Here, the authors use FRET assays to show that RING E3 ligases transfer ubiquitin to the substrate from a closed E2~Ub conformation.
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Main Authors: | , , |
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Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2020
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Subjects: | |
Online Access: | https://doaj.org/article/804ead47bc3a4058bfc76e0bf7df8968 |
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