Ubiquitin transfer by a RING E3 ligase occurs from a closed E2~ubiquitin conformation

The mechanism of ubiquitin transfer from the ubiquitin-conjugated E2 enzyme (E2~Ub) to the substrate is still under debate. Here, the authors use FRET assays to show that RING E3 ligases transfer ubiquitin to the substrate from a closed E2~Ub conformation.

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Bibliographic Details
Main Authors: Emma Branigan, J. Carlos Penedo, Ronald T. Hay
Format: article
Language:EN
Published: Nature Portfolio 2020
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Online Access:https://doaj.org/article/804ead47bc3a4058bfc76e0bf7df8968
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