Ubiquitin transfer by a RING E3 ligase occurs from a closed E2~ubiquitin conformation

The mechanism of ubiquitin transfer from the ubiquitin-conjugated E2 enzyme (E2~Ub) to the substrate is still under debate. Here, the authors use FRET assays to show that RING E3 ligases transfer ubiquitin to the substrate from a closed E2~Ub conformation.

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Autores principales:	Emma Branigan, J. Carlos Penedo, Ronald T. Hay
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/804ead47bc3a4058bfc76e0bf7df8968
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spelling	oai:doaj.org-article:804ead47bc3a4058bfc76e0bf7df89682021-12-02T18:24:58ZUbiquitin transfer by a RING E3 ligase occurs from a closed E2~ubiquitin conformation10.1038/s41467-020-16666-y2041-1723https://doaj.org/article/804ead47bc3a4058bfc76e0bf7df89682020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16666-yhttps://doaj.org/toc/2041-1723The mechanism of ubiquitin transfer from the ubiquitin-conjugated E2 enzyme (E2~Ub) to the substrate is still under debate. Here, the authors use FRET assays to show that RING E3 ligases transfer ubiquitin to the substrate from a closed E2~Ub conformation.Emma BraniganJ. Carlos PenedoRonald T. HayNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Emma Branigan J. Carlos Penedo Ronald T. Hay Ubiquitin transfer by a RING E3 ligase occurs from a closed E2~ubiquitin conformation
description	The mechanism of ubiquitin transfer from the ubiquitin-conjugated E2 enzyme (E2~Ub) to the substrate is still under debate. Here, the authors use FRET assays to show that RING E3 ligases transfer ubiquitin to the substrate from a closed E2~Ub conformation.
format	article
author	Emma Branigan J. Carlos Penedo Ronald T. Hay
author_facet	Emma Branigan J. Carlos Penedo Ronald T. Hay
author_sort	Emma Branigan
title	Ubiquitin transfer by a RING E3 ligase occurs from a closed E2~ubiquitin conformation
title_short	Ubiquitin transfer by a RING E3 ligase occurs from a closed E2~ubiquitin conformation
title_full	Ubiquitin transfer by a RING E3 ligase occurs from a closed E2~ubiquitin conformation
title_fullStr	Ubiquitin transfer by a RING E3 ligase occurs from a closed E2~ubiquitin conformation
title_full_unstemmed	Ubiquitin transfer by a RING E3 ligase occurs from a closed E2~ubiquitin conformation
title_sort	ubiquitin transfer by a ring e3 ligase occurs from a closed e2~ubiquitin conformation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/804ead47bc3a4058bfc76e0bf7df8968
work_keys_str_mv	AT emmabranigan ubiquitintransferbyaringe3ligaseoccursfromaclosede2ubiquitinconformation AT jcarlospenedo ubiquitintransferbyaringe3ligaseoccursfromaclosede2ubiquitinconformation AT ronaldthay ubiquitintransferbyaringe3ligaseoccursfromaclosede2ubiquitinconformation
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Ubiquitin transfer by a RING E3 ligase occurs from a closed E2~ubiquitin conformation

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