Cx26 drives self-renewal in triple-negative breast cancer via interaction with NANOG and focal adhesion kinase

Connexin proteins are usually considered as tumor suppressors. Here, the authors show that connexin 26 (Cx26) regulates the self-renewal of breast cancer stem cells via a ternary complex with FAK and NANOG.

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Autores principales:	Praveena S. Thiagarajan, Maksim Sinyuk, Soumya M. Turaga, Erin E. Mulkearns-Hubert, James S. Hale, Vinay Rao, Abeba Demelash, Caner Saygin, Arnab China, Tyler J. Alban, Masahiro Hitomi, Luke A. Torre-Healy, Alvaro G. Alvarado, Awad Jarrar, Andrew Wiechert, Valery Adorno-Cruz, Paul L. Fox, Benjamin C. Calhoun, Jun-Lin Guan, Huiping Liu, Ofer Reizes, Justin D. Lathia
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8069efa147334bedbe33b1e19b4d7241
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spelling	oai:doaj.org-article:8069efa147334bedbe33b1e19b4d72412021-12-02T16:56:41ZCx26 drives self-renewal in triple-negative breast cancer via interaction with NANOG and focal adhesion kinase10.1038/s41467-018-02938-12041-1723https://doaj.org/article/8069efa147334bedbe33b1e19b4d72412018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-02938-1https://doaj.org/toc/2041-1723Connexin proteins are usually considered as tumor suppressors. Here, the authors show that connexin 26 (Cx26) regulates the self-renewal of breast cancer stem cells via a ternary complex with FAK and NANOG.Praveena S. ThiagarajanMaksim SinyukSoumya M. TuragaErin E. Mulkearns-HubertJames S. HaleVinay RaoAbeba DemelashCaner SayginArnab ChinaTyler J. AlbanMasahiro HitomiLuke A. Torre-HealyAlvaro G. AlvaradoAwad JarrarAndrew WiechertValery Adorno-CruzPaul L. FoxBenjamin C. CalhounJun-Lin GuanHuiping LiuOfer ReizesJustin D. LathiaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Praveena S. Thiagarajan Maksim Sinyuk Soumya M. Turaga Erin E. Mulkearns-Hubert James S. Hale Vinay Rao Abeba Demelash Caner Saygin Arnab China Tyler J. Alban Masahiro Hitomi Luke A. Torre-Healy Alvaro G. Alvarado Awad Jarrar Andrew Wiechert Valery Adorno-Cruz Paul L. Fox Benjamin C. Calhoun Jun-Lin Guan Huiping Liu Ofer Reizes Justin D. Lathia Cx26 drives self-renewal in triple-negative breast cancer via interaction with NANOG and focal adhesion kinase
description	Connexin proteins are usually considered as tumor suppressors. Here, the authors show that connexin 26 (Cx26) regulates the self-renewal of breast cancer stem cells via a ternary complex with FAK and NANOG.
format	article
author	Praveena S. Thiagarajan Maksim Sinyuk Soumya M. Turaga Erin E. Mulkearns-Hubert James S. Hale Vinay Rao Abeba Demelash Caner Saygin Arnab China Tyler J. Alban Masahiro Hitomi Luke A. Torre-Healy Alvaro G. Alvarado Awad Jarrar Andrew Wiechert Valery Adorno-Cruz Paul L. Fox Benjamin C. Calhoun Jun-Lin Guan Huiping Liu Ofer Reizes Justin D. Lathia
author_facet	Praveena S. Thiagarajan Maksim Sinyuk Soumya M. Turaga Erin E. Mulkearns-Hubert James S. Hale Vinay Rao Abeba Demelash Caner Saygin Arnab China Tyler J. Alban Masahiro Hitomi Luke A. Torre-Healy Alvaro G. Alvarado Awad Jarrar Andrew Wiechert Valery Adorno-Cruz Paul L. Fox Benjamin C. Calhoun Jun-Lin Guan Huiping Liu Ofer Reizes Justin D. Lathia
author_sort	Praveena S. Thiagarajan
title	Cx26 drives self-renewal in triple-negative breast cancer via interaction with NANOG and focal adhesion kinase
title_short	Cx26 drives self-renewal in triple-negative breast cancer via interaction with NANOG and focal adhesion kinase
title_full	Cx26 drives self-renewal in triple-negative breast cancer via interaction with NANOG and focal adhesion kinase
title_fullStr	Cx26 drives self-renewal in triple-negative breast cancer via interaction with NANOG and focal adhesion kinase
title_full_unstemmed	Cx26 drives self-renewal in triple-negative breast cancer via interaction with NANOG and focal adhesion kinase
title_sort	cx26 drives self-renewal in triple-negative breast cancer via interaction with nanog and focal adhesion kinase
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/8069efa147334bedbe33b1e19b4d7241
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Cx26 drives self-renewal in triple-negative breast cancer via interaction with NANOG and focal adhesion kinase

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