Apple procyanidins promote mitochondrial biogenesis and proteoglycan biosynthesis in chondrocytes

Abstract Apples are well known to have various benefits for the human body. Procyanidins are a class of polyphenols found in apples that have demonstrated effects on the circulatory system and skeletal organs. Osteoarthritis (OA) is a locomotive syndrome that is histologically characterized by carti...

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Autores principales:	Isao Masuda, Masato Koike, Shohei Nakashima, Yu Mizutani, Yusuke Ozawa, Kenji Watanabe, Yoko Sawada, Hiroshi Sugiyama, Atsushi Sugimoto, Hidetoshi Nojiri, Koichi Sashihara, Koutaro Yokote, Takahiko Shimizu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/807631a87310403fad916501ca20c8ed
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spelling	oai:doaj.org-article:807631a87310403fad916501ca20c8ed2021-12-02T15:08:11ZApple procyanidins promote mitochondrial biogenesis and proteoglycan biosynthesis in chondrocytes10.1038/s41598-018-25348-12045-2322https://doaj.org/article/807631a87310403fad916501ca20c8ed2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25348-1https://doaj.org/toc/2045-2322Abstract Apples are well known to have various benefits for the human body. Procyanidins are a class of polyphenols found in apples that have demonstrated effects on the circulatory system and skeletal organs. Osteoarthritis (OA) is a locomotive syndrome that is histologically characterized by cartilage degeneration associated with the impairment of proteoglycan homeostasis in chondrocytes. However, no useful therapy for cartilage degeneration has been developed to date. In the present study, we detected beneficial effects of apple polyphenols or their procyanidins on cartilage homeostasis. An in vitro assay revealed that apple polyphenols increased the activities of mitochondrial dehydrogenases associated with an increased copy number of mitochondrial DNA as well as the gene expression of peroxisome proliferator-activated receptor gamma coactivator 1-α (PGC-1α), suggesting the promotion of PGC-1α-mediated mitochondrial biogenesis. Apple procyanidins also enhanced proteoglycan biosynthesis with aggrecan upregulation in primary chondrocytes. Of note, oral treatment with apple procyanidins prevented articular cartilage degradation in OA model mice induced by mitochondrial dysfunction in chondrocytes. Our findings suggest that apple procyanidins are promising food components that inhibit OA progression by promoting mitochondrial biogenesis and proteoglycan homeostasis in chondrocytes.Isao MasudaMasato KoikeShohei NakashimaYu MizutaniYusuke OzawaKenji WatanabeYoko SawadaHiroshi SugiyamaAtsushi SugimotoHidetoshi NojiriKoichi SashiharaKoutaro YokoteTakahiko ShimizuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Isao Masuda Masato Koike Shohei Nakashima Yu Mizutani Yusuke Ozawa Kenji Watanabe Yoko Sawada Hiroshi Sugiyama Atsushi Sugimoto Hidetoshi Nojiri Koichi Sashihara Koutaro Yokote Takahiko Shimizu Apple procyanidins promote mitochondrial biogenesis and proteoglycan biosynthesis in chondrocytes
description	Abstract Apples are well known to have various benefits for the human body. Procyanidins are a class of polyphenols found in apples that have demonstrated effects on the circulatory system and skeletal organs. Osteoarthritis (OA) is a locomotive syndrome that is histologically characterized by cartilage degeneration associated with the impairment of proteoglycan homeostasis in chondrocytes. However, no useful therapy for cartilage degeneration has been developed to date. In the present study, we detected beneficial effects of apple polyphenols or their procyanidins on cartilage homeostasis. An in vitro assay revealed that apple polyphenols increased the activities of mitochondrial dehydrogenases associated with an increased copy number of mitochondrial DNA as well as the gene expression of peroxisome proliferator-activated receptor gamma coactivator 1-α (PGC-1α), suggesting the promotion of PGC-1α-mediated mitochondrial biogenesis. Apple procyanidins also enhanced proteoglycan biosynthesis with aggrecan upregulation in primary chondrocytes. Of note, oral treatment with apple procyanidins prevented articular cartilage degradation in OA model mice induced by mitochondrial dysfunction in chondrocytes. Our findings suggest that apple procyanidins are promising food components that inhibit OA progression by promoting mitochondrial biogenesis and proteoglycan homeostasis in chondrocytes.
format	article
author	Isao Masuda Masato Koike Shohei Nakashima Yu Mizutani Yusuke Ozawa Kenji Watanabe Yoko Sawada Hiroshi Sugiyama Atsushi Sugimoto Hidetoshi Nojiri Koichi Sashihara Koutaro Yokote Takahiko Shimizu
author_facet	Isao Masuda Masato Koike Shohei Nakashima Yu Mizutani Yusuke Ozawa Kenji Watanabe Yoko Sawada Hiroshi Sugiyama Atsushi Sugimoto Hidetoshi Nojiri Koichi Sashihara Koutaro Yokote Takahiko Shimizu
author_sort	Isao Masuda
title	Apple procyanidins promote mitochondrial biogenesis and proteoglycan biosynthesis in chondrocytes
title_short	Apple procyanidins promote mitochondrial biogenesis and proteoglycan biosynthesis in chondrocytes
title_full	Apple procyanidins promote mitochondrial biogenesis and proteoglycan biosynthesis in chondrocytes
title_fullStr	Apple procyanidins promote mitochondrial biogenesis and proteoglycan biosynthesis in chondrocytes
title_full_unstemmed	Apple procyanidins promote mitochondrial biogenesis and proteoglycan biosynthesis in chondrocytes
title_sort	apple procyanidins promote mitochondrial biogenesis and proteoglycan biosynthesis in chondrocytes
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/807631a87310403fad916501ca20c8ed
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Apple procyanidins promote mitochondrial biogenesis and proteoglycan biosynthesis in chondrocytes

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