Septal Class A Penicillin-Binding Protein Activity and <scp>ld</scp> -Transpeptidases Mediate Selection of Colistin-Resistant Lipooligosaccharide-Deficient Acinetobacter baumannii

The increasing prevalence of antibiotic treatment failure associated with Gram-negative bacterial infections highlights an urgent need to develop new alternative therapeutic strategies. The last-line antimicrobial colistin (polymyxin E) targets the ubiquitous outer membrane lipopolysaccharide (LPS)...

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Autores principales:	Katie N. Kang, Misha I. Kazi, Jacob Biboy, Joe Gray, Hannah Bovermann, Jessie Ausman, Cara C. Boutte, Waldemar Vollmer, Joseph M. Boll
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2021
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/8086c873e9aa4506bcc2a0b60a6154f6
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spelling	oai:doaj.org-article:8086c873e9aa4506bcc2a0b60a6154f62021-11-03T18:15:38Z Septal Class A Penicillin-Binding Protein Activity and <scp>ld</scp> -Transpeptidases Mediate Selection of Colistin-Resistant Lipooligosaccharide-Deficient Acinetobacter baumannii 2161-21292150-751110.1128/mBio.02185-20https://doaj.org/article/8086c873e9aa4506bcc2a0b60a6154f62021-02-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.02185-20https://doaj.org/toc/2161-2129https://doaj.org/toc/2150-7511 The increasing prevalence of antibiotic treatment failure associated with Gram-negative bacterial infections highlights an urgent need to develop new alternative therapeutic strategies. The last-line antimicrobial colistin (polymyxin E) targets the ubiquitous outer membrane lipopolysaccharide (LPS)/LOS membrane anchor, lipid A, which is essential for viability of most diderms.Katie N. KangMisha I. KaziJacob BiboyJoe GrayHannah BovermannJessie AusmanCara C. BoutteWaldemar VollmerJoseph M. BollAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 12, Iss 1 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Katie N. Kang Misha I. Kazi Jacob Biboy Joe Gray Hannah Bovermann Jessie Ausman Cara C. Boutte Waldemar Vollmer Joseph M. Boll Septal Class A Penicillin-Binding Protein Activity and <scp>ld</scp> -Transpeptidases Mediate Selection of Colistin-Resistant Lipooligosaccharide-Deficient Acinetobacter baumannii
description	The increasing prevalence of antibiotic treatment failure associated with Gram-negative bacterial infections highlights an urgent need to develop new alternative therapeutic strategies. The last-line antimicrobial colistin (polymyxin E) targets the ubiquitous outer membrane lipopolysaccharide (LPS)/LOS membrane anchor, lipid A, which is essential for viability of most diderms.
format	article
author	Katie N. Kang Misha I. Kazi Jacob Biboy Joe Gray Hannah Bovermann Jessie Ausman Cara C. Boutte Waldemar Vollmer Joseph M. Boll
author_facet	Katie N. Kang Misha I. Kazi Jacob Biboy Joe Gray Hannah Bovermann Jessie Ausman Cara C. Boutte Waldemar Vollmer Joseph M. Boll
author_sort	Katie N. Kang
title	Septal Class A Penicillin-Binding Protein Activity and <scp>ld</scp> -Transpeptidases Mediate Selection of Colistin-Resistant Lipooligosaccharide-Deficient Acinetobacter baumannii
title_short	Septal Class A Penicillin-Binding Protein Activity and <scp>ld</scp> -Transpeptidases Mediate Selection of Colistin-Resistant Lipooligosaccharide-Deficient Acinetobacter baumannii
title_full	Septal Class A Penicillin-Binding Protein Activity and <scp>ld</scp> -Transpeptidases Mediate Selection of Colistin-Resistant Lipooligosaccharide-Deficient Acinetobacter baumannii
title_fullStr	Septal Class A Penicillin-Binding Protein Activity and <scp>ld</scp> -Transpeptidases Mediate Selection of Colistin-Resistant Lipooligosaccharide-Deficient Acinetobacter baumannii
title_full_unstemmed	Septal Class A Penicillin-Binding Protein Activity and <scp>ld</scp> -Transpeptidases Mediate Selection of Colistin-Resistant Lipooligosaccharide-Deficient Acinetobacter baumannii
title_sort	septal class a penicillin-binding protein activity and <scp>ld</scp> -transpeptidases mediate selection of colistin-resistant lipooligosaccharide-deficient acinetobacter baumannii
publisher	American Society for Microbiology
publishDate	2021
url	https://doaj.org/article/8086c873e9aa4506bcc2a0b60a6154f6
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Septal Class A Penicillin-Binding Protein Activity and <scp>ld</scp> -Transpeptidases Mediate Selection of Colistin-Resistant Lipooligosaccharide-Deficient Acinetobacter baumannii

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