Vertically transferred maternal immune cells promote neonatal immunity against early life infections
Maternal immune cells seed into the foetus during mammalian pregnancy, yet the functional role of these cells is unclear. Here the authors show that maternal immune cells in foetal bone marrow stimulate immune development, subsequently reducing the risk or severity of infections in newborns.
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Nature Portfolio
2021
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oai:doaj.org-article:8088a7cf93724a69801b759e6eac591e2021-12-02T18:49:22ZVertically transferred maternal immune cells promote neonatal immunity against early life infections10.1038/s41467-021-24719-z2041-1723https://doaj.org/article/8088a7cf93724a69801b759e6eac591e2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24719-zhttps://doaj.org/toc/2041-1723Maternal immune cells seed into the foetus during mammalian pregnancy, yet the functional role of these cells is unclear. Here the authors show that maternal immune cells in foetal bone marrow stimulate immune development, subsequently reducing the risk or severity of infections in newborns.Ina Annelies StelzerChristopher UrbschatSteven SchepanskiKristin ThieleIoanna TriviaiAgnes WieczorekMalik AlawiDenise OhnezeitJulian KottlauJiabin HuangNicole FischerHans-Willi MittrückerMaria Emilia SolanoBoris FehseAnke DiemertFelix R. StahlPetra Clara ArckNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Ina Annelies Stelzer Christopher Urbschat Steven Schepanski Kristin Thiele Ioanna Triviai Agnes Wieczorek Malik Alawi Denise Ohnezeit Julian Kottlau Jiabin Huang Nicole Fischer Hans-Willi Mittrücker Maria Emilia Solano Boris Fehse Anke Diemert Felix R. Stahl Petra Clara Arck Vertically transferred maternal immune cells promote neonatal immunity against early life infections |
| description |
Maternal immune cells seed into the foetus during mammalian pregnancy, yet the functional role of these cells is unclear. Here the authors show that maternal immune cells in foetal bone marrow stimulate immune development, subsequently reducing the risk or severity of infections in newborns. |
| format |
article |
| author |
Ina Annelies Stelzer Christopher Urbschat Steven Schepanski Kristin Thiele Ioanna Triviai Agnes Wieczorek Malik Alawi Denise Ohnezeit Julian Kottlau Jiabin Huang Nicole Fischer Hans-Willi Mittrücker Maria Emilia Solano Boris Fehse Anke Diemert Felix R. Stahl Petra Clara Arck |
| author_facet |
Ina Annelies Stelzer Christopher Urbschat Steven Schepanski Kristin Thiele Ioanna Triviai Agnes Wieczorek Malik Alawi Denise Ohnezeit Julian Kottlau Jiabin Huang Nicole Fischer Hans-Willi Mittrücker Maria Emilia Solano Boris Fehse Anke Diemert Felix R. Stahl Petra Clara Arck |
| author_sort |
Ina Annelies Stelzer |
| title |
Vertically transferred maternal immune cells promote neonatal immunity against early life infections |
| title_short |
Vertically transferred maternal immune cells promote neonatal immunity against early life infections |
| title_full |
Vertically transferred maternal immune cells promote neonatal immunity against early life infections |
| title_fullStr |
Vertically transferred maternal immune cells promote neonatal immunity against early life infections |
| title_full_unstemmed |
Vertically transferred maternal immune cells promote neonatal immunity against early life infections |
| title_sort |
vertically transferred maternal immune cells promote neonatal immunity against early life infections |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/8088a7cf93724a69801b759e6eac591e |
| work_keys_str_mv |
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