Nuclear egress of TDP-43 and FUS occurs independently of Exportin-1/CRM1

Nuclear egress of TDP-43 and FUS occurs independently of Exportin-1/CRM1

Abstract TDP-43 and FUS are nuclear proteins with multiple functions in mRNA processing. They play key roles in ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia), where they are partially lost from the nucleus and aggregate in the cytoplasm of neurons and glial cells. Defects in...

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Bibliographic Details
Main Authors: Helena Ederle, Christina Funk, Claudia Abou-Ajram, Saskia Hutten, Eva B. E. Funk, Ralph H. Kehlenbach, Susanne M. Bailer, Dorothee Dormann
Format: article
Language:EN
Published: Nature Portfolio 2018
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/8094611fcf1f43b9ba32a1e651adbced
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