Histone deacetylase 8 is required for centrosome cohesion and influenza A virus entry.

Influenza A virus (IAV) enters host cells by endocytosis followed by acid-activated penetration from late endosomes (LEs). Using siRNA silencing, we found that histone deacetylase 8 (HDAC8), a cytoplasmic enzyme, efficiently promoted productive entry of IAV into tissue culture cells, whereas HDAC1 s...

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Autores principales: Yohei Yamauchi, Heithem Boukari, Indranil Banerjee, Ivo F Sbalzarini, Peter Horvath, Ari Helenius
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
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Acceso en línea:https://doaj.org/article/80a38b8b1c574a3699c6581885e7aa07
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