Dietary flavonoid intake and smoking-related cancer risk: a meta-analysis.

<h4>Purpose</h4>To systematically investigate the effects of dietary flavonoids and flavonoid subclasses on the risk of smoking-related cancer in observational studies.<h4>Methods</h4>Summary estimates and corresponding standard errors were calculated using the multivariate-a...

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Autores principales:	Hae Dong Woo, Jeongseon Kim
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/80d719bdda7d4516828dfd8945718300
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spelling	oai:doaj.org-article:80d719bdda7d4516828dfd89457183002021-11-18T08:54:29ZDietary flavonoid intake and smoking-related cancer risk: a meta-analysis.1932-620310.1371/journal.pone.0075604https://doaj.org/article/80d719bdda7d4516828dfd89457183002013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24069431/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Purpose</h4>To systematically investigate the effects of dietary flavonoids and flavonoid subclasses on the risk of smoking-related cancer in observational studies.<h4>Methods</h4>Summary estimates and corresponding standard errors were calculated using the multivariate-adjusted odds ratio (OR) or relative risk (RR) and 95% CI of selected studies and weighted by the inverse variance.<h4>Results</h4>A total of 35 studies, including 19 case-controls (9,525 cases and 15,835 controls) and 15 cohort studies (988,082 subjects and 8,161 cases), were retrieved for the meta-analysis. Total dietary flavonoids and most of the flavonoid subclasses were inversely associated with smoking-related cancer risk (OR: 0.82, 95% CI: 0.72-0.93). In subgroup analyses by cancer site, significant associations were observed in aerodigestive tract and lung cancers. Total dietary flavonoid intake was significantly associated with aerodigestive tract cancer risk (OR: 0.67, 95% CI: 0.54-0.83) marginally associated with lung cancer risk (OR: 0.84, 95% CI: 0.71-1.00). Subgroup analyses by smoking status showed significantly different results. The intake of total flavonoids, flavonols, flavones, and flavanones, as well as the flavonols quercetin and kaempferol was significantly associated with decreased risk of smoking-related cancer in smokers, whereas no association was observed in non-smokers, except for flavanones. In meta-analysis for the effect of subclasses of dietary flavonoids by cancer type, aerodigestive tract cancer was inversely associated with most flavonoid subclasses.<h4>Conclusion</h4>The protective effects of flavonoids on smoking-related cancer risk varied across studies, but the overall results indicated that intake of dietary flavonoids, especially flavonols, was inversely associated with smoking-related cancer risk. The protective effects of flavonoids on smoking-related cancer risk were more prominent in smokers.Hae Dong WooJeongseon KimPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 9, p e75604 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hae Dong Woo Jeongseon Kim Dietary flavonoid intake and smoking-related cancer risk: a meta-analysis.
description	<h4>Purpose</h4>To systematically investigate the effects of dietary flavonoids and flavonoid subclasses on the risk of smoking-related cancer in observational studies.<h4>Methods</h4>Summary estimates and corresponding standard errors were calculated using the multivariate-adjusted odds ratio (OR) or relative risk (RR) and 95% CI of selected studies and weighted by the inverse variance.<h4>Results</h4>A total of 35 studies, including 19 case-controls (9,525 cases and 15,835 controls) and 15 cohort studies (988,082 subjects and 8,161 cases), were retrieved for the meta-analysis. Total dietary flavonoids and most of the flavonoid subclasses were inversely associated with smoking-related cancer risk (OR: 0.82, 95% CI: 0.72-0.93). In subgroup analyses by cancer site, significant associations were observed in aerodigestive tract and lung cancers. Total dietary flavonoid intake was significantly associated with aerodigestive tract cancer risk (OR: 0.67, 95% CI: 0.54-0.83) marginally associated with lung cancer risk (OR: 0.84, 95% CI: 0.71-1.00). Subgroup analyses by smoking status showed significantly different results. The intake of total flavonoids, flavonols, flavones, and flavanones, as well as the flavonols quercetin and kaempferol was significantly associated with decreased risk of smoking-related cancer in smokers, whereas no association was observed in non-smokers, except for flavanones. In meta-analysis for the effect of subclasses of dietary flavonoids by cancer type, aerodigestive tract cancer was inversely associated with most flavonoid subclasses.<h4>Conclusion</h4>The protective effects of flavonoids on smoking-related cancer risk varied across studies, but the overall results indicated that intake of dietary flavonoids, especially flavonols, was inversely associated with smoking-related cancer risk. The protective effects of flavonoids on smoking-related cancer risk were more prominent in smokers.
format	article
author	Hae Dong Woo Jeongseon Kim
author_facet	Hae Dong Woo Jeongseon Kim
author_sort	Hae Dong Woo
title	Dietary flavonoid intake and smoking-related cancer risk: a meta-analysis.
title_short	Dietary flavonoid intake and smoking-related cancer risk: a meta-analysis.
title_full	Dietary flavonoid intake and smoking-related cancer risk: a meta-analysis.
title_fullStr	Dietary flavonoid intake and smoking-related cancer risk: a meta-analysis.
title_full_unstemmed	Dietary flavonoid intake and smoking-related cancer risk: a meta-analysis.
title_sort	dietary flavonoid intake and smoking-related cancer risk: a meta-analysis.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/80d719bdda7d4516828dfd8945718300
work_keys_str_mv	AT haedongwoo dietaryflavonoidintakeandsmokingrelatedcancerriskametaanalysis AT jeongseonkim dietaryflavonoidintakeandsmokingrelatedcancerriskametaanalysis
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Dietary flavonoid intake and smoking-related cancer risk: a meta-analysis.

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