Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes

Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes

Astrocytes are important players in brain development, homeostasis, and disease. Here, the authors compare the transcriptional profiles of human and mouse astrocytes. They report species-specific susceptibility to oxidative stress and response to hypoxic and inflammatory conditions.

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Bibliographic Details
Main Authors: Jiwen Li, Lin Pan, William G. Pembroke, Jessica E. Rexach, Marlesa I. Godoy, Michael C. Condro, Alvaro G. Alvarado, Mineli Harteni, Yen-Wei Chen, Linsey Stiles, Angela Y. Chen, Ina B. Wanner, Xia Yang, Steven A. Goldman, Daniel H. Geschwind, Harley I. Kornblum, Ye Zhang
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Science
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Online Access:https://doaj.org/article/80da4dfa224845c2a806b159e42df65d
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Summary:Astrocytes are important players in brain development, homeostasis, and disease. Here, the authors compare the transcriptional profiles of human and mouse astrocytes. They report species-specific susceptibility to oxidative stress and response to hypoxic and inflammatory conditions.

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