Structural basis for DNA damage-induced phosphoregulation of MDM2 RING domain

Structural basis for DNA damage-induced phosphoregulation of MDM2 RING domain

p53 is an important tumor suppressor protein which is regulated by the E3 ubiquitin ligase MDM2. Here the authors reveal that DNA damage-induced Ser429 phosphorylation of MDM2 serve to boost the activity of MDM2 homodimer by stabilizing the active E2–ubiquitin complex and promote its self-destructio...

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Bibliographic Details
Main Authors: Helge M. Magnussen, Syed F. Ahmed, Gary. J. Sibbet, Ventzislava A. Hristova, Koji Nomura, Andreas K. Hock, Lewis J. Archibald, Andrew G. Jamieson, David Fushman, Karen H. Vousden, Allan M. Weissman, Danny T. Huang
Format: article
Language:EN
Published: Nature Portfolio 2020
Subjects:
Science
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Online Access:https://doaj.org/article/80e8bf383dda460bb88d16b6b1cd6555
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