Geometrically defined environments direct cell division rate and subcellular YAP localization in single mouse embryonic stem cells

Abstract Mechanotransduction via yes-associated protein (YAP) is a central mechanism for decision-making in mouse embryonic stem cells (mESCs). Nuclear localization of YAP is tightly connected to pluripotency and increases the cell division rate (CDR). How the geometry of the extracellular environme...

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Auteurs principaux: Sarah Bertels, Mona Jaggy, Benjamin Richter, Stephan Keppler, Kerstin Weber, Elisa Genthner, Andrea C. Fischer, Michael Thiel, Martin Wegener, Alexandra M. Greiner, Tatjana J. Autenrieth, Martin Bastmeyer
Format: article
Langue:EN
Publié: Nature Portfolio 2021
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Accès en ligne:https://doaj.org/article/80ffe03679444a2aa6e0e27b7e0d2b1e
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